Browsing by Author "Zemtsov, Alexander"

Now showing 1 - 4 of 4
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    From bedside to genetic analysis: New insights into pathophysiology of melanoma, basal cell carcinoma, and other cancers
    (Wiley, 2024) Zemtsov, Alexander; Dermatology, School of Medicine
    Objective: Patients with myotonic muscular dystrophy (MMD) were observed to have numerous basal cell carcinoma (BCC) and abnormal dysplastic nevi (DN) on non-sun exposed skin. Simultaneously a large study published in the Journal of American Medical Association (JAMA) illustrated that patients with MMD have "overall" an increased risk for cancer development. Based on these findings, this author in 2010 postulated that dysregulation of RNA binding proteins (RBP), responsible for clinical manifestations of MMD, is also responsible for the development of BCC and melanoma. Methods: To report new research elucidating the etiology of melanoma, BCC, MMD-induced cancers, and potentially other environmentally induced malignancies. Results: Dysregulation of RBP induces aberrant mRNA splicing; recent data indicates that abnormal mRNA splicing not just plays a key role in the pathogenesis of melanoma but is a hallmark of essentially all human malignancies. Conclusion: The author's hypothesis is that ultraviolet (UV) radiation induces DNA damage in intronic regions of a variety of genes. Furthermore, these UV-induced abnormal DNA dimers, repeats and mutations interfere with normal mRNA splicing thus producing abnormal proteins. These abnormal proteins in turn activate oncogenic pathways such as hedgehog, MAP kinase, and WNT.
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    Lichenoid Reaction Pattern with Pseudoepitheliomatous Hyperplasia - A Rare Tattoo Reaction: A Case Report and Review of the Literature
    (Karger, 2018-12-05) Broussard-Steinberg, Candace; Zemtsov, Alexander; Strausburg, Matthew; Zemtsov, Gregory; Warren, Simon; Dermatology, School of Medicine
    Pseudoepitheliomatous hyperplasia is a benign histologic reaction pattern that in rare cases can occur shortly after a tattooing procedure. We describe a case of pseudoepitheliomatous hyperplasia in two tattoos on the same patient 1 year after filling with the same batch of red ink.
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    Proposed guidelines for appropriate utilization of superficial radiation therapy in management of skin cancers. Zemtsov‐Cognetta criteria
    (Wiley, 2023) Zemtsov, Alexander; Cognetta, Armand; Marvel, John; Logan, Ann; Dermatology, School of Medicine
    Objective: To develop appropriate use criteria (AUC) for the treatment of basal cell and squamous cell carcinoma by superficial radiation therapy (SRT) technique. Material and methods: Delphi-type discussion of the experts. Results: Presented in Figure 1. Conclusion: These AUCs are in compliance both with the position statement of the American Academy of Dermatology (AAD) and the ASTRO Clinical Practice Guideline on this subject. It is further recommended that SRT will be only performed by either a dermatologist who is board certified in Mohs surgery (MDS) and who had adequate SRT training or by radiation oncologists. Hopefully, this publication will stimulate further discussion on this topic.
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    Skin ultrasonography and magnetic resonance; new clinical applications and instrumentation
    (Wiley, 2024) Zemtsov, Alexander; Dermatology, School of Medicine
    Background: Technological advances in skin ultrasonography and magnetic resonance are discussed. Methods: Literature review. Results: 40 publications cited. Conclusion: This article illustrates crucial contributions made by the Editors, the Editorial Board and this Journal to these fields.