Browsing by Author "Younes, Mohamad"

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    Hyperammonemic Encephalopathy: A Rare Presentation of Relapsed Multiple Myeloma
    (Elmer Press, 2023) Menakuru, Sasmith R.; Atta, Mona; Ammannagari, Nischala; Younes, Mohamad; Medicine, School of Medicine
    Hyperammonemia is a rare cause of encephalopathy in multiple myeloma in the absence of hepatic involvement. This is the only reported case of a 74-year-old man who presented with multiple myeloma and achieved complete remission but developed hyperammonemia afterward. He was aggressively treated with a combination of chemotherapy and immunotherapy, with a resolution of his encephalopathy; however, within one month, he relapsed with encephalopathy. He ultimately decided to pursue comfort-care measures. The authors conclude that hyperammonemia in multiple myeloma is a rare but important differential in patients with encephalopathy of unknown causes. Aggressive treatment is of the utmost importance due to the high mortality associated with the condition.