Browsing by Author "Yin, Ji-Ye"

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    eIF3 Regulation of Protein Synthesis, Tumorigenesis, and Therapeutic Response
    (SpringerLink, 2017) Yin, Ji-Ye; Dong, Zizheng; Zhang, Jian-Ting; Pharmacology and Toxicology, School of Medicine
    Translation initiation is the rate-limiting step of protein synthesis and highly regulated. Eukaryotic initiation factor 3 (eIF3) is the largest and most complex initiation factor consisting of 13 putative subunits. A growing number of studies suggest that eIF3 and its subunits may represent a new group of proto- oncogenes and associates with prognosis. They regulate translation of a subset of mRNAs involved in many cellular processes including proliferation, apoptosis, DNA repair, and cell cycle. Therefore, unveiling the mechanisms of eIF3 action in tumorigenesis may help identify attractive targets for cancer therapy. Here, we describe a series of methods used in the study of eIF3 function in regulating protein synthesis, tumorigenesis, and cellular response to therapeutic treatments.
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    eIF3a: A new anticancer drug target in the eIF family
    (Elsevier, 2018-01) Yin, Ji-Ye; Zhang, Jian-Ting; Zhang, Wei; Zhou, Hong-Hao; Liu, Zhao-Qian; Pharmacology and Toxicology, School of Medicine
    eIF3a is the largest subunit of eIF3, which is a key player in all steps of translation initiation. During the past years, eIF3a is recognized as a proto-oncogene, which is an important discovery in this field. It is widely reported to be correlated with cancer occurrence, metastasis, prognosis, and therapeutic response. Recently, the mechanisms of eIF3a action in the carcinogenesis are unveiled gradually. A number of cellular, physiological, and pathological processes involving eIF3a are identified. Most importantly, it is emerging as a new potential drug target in the eIF family, and some small molecule inhibitors are being developed. Thus, we perform a critical review of recent advances in understanding eIF3a physiological and pathological functions, with specific focus on its role in cancer and anticancer drug targets.