Browsing by Author "Yard, Michael"

Now showing 1 - 6 of 6
  • Thumbnail Image
    Item
    Cleft Lip and Palate Literature Review Compilation
    (Office of the Vice Chancellor for Research, 2015-04-17) Khan, Abdul Karim; Yard, Michael
    The purpose of this review is to provide a summary of the cleft lip or palate procedure with a focus on human anatomy and physiology. Cleft lip and palate are the most common facial malformations and occur in 1 newborn in 2500 live births. Through a thorough analysis of journal articles and viable sources one can grasp an introductory understanding of cleft palate including the history, anatomy, causes, procedure, and post-operation lifestyle with cleft palate. Although the problem is genetic and embryological in nature, anatomy is relevant as the complications stem from oropharyngeal muscles inserting on structural bones, impacting neurovascular areas of the mouth, leading to a complex deformity. The topic was subdivided to cover all areas relevant to the review. The sources used were primarily from journal articles such as PubMed, books, and other online published data. Overall the topic is closely related to medicine and dentistry while incorporating basic anatomical concepts.
  • Thumbnail Image
    Item
    Construction of a Database for Socio-Demographic, Medico-Legal, Anatomic, and Genomic Research into Suicide
    (Office of the Vice Chancellor for Research, 2015-04-17) Engle, Kaitlyn; Cook, Shannon; Levey, Daniel; Ballew, Alfarena; Yard, Michael
    Suicide is a potentially preventable tragedy. Over 180 cases of suicide a year occur in Marion County. We have created a database that permits integration of socio-demographic data, medico-legal information, anatomic images, and genomic results. We have collected over 50 cases to date. We will show results of analyses looking at method of suicide, toxicology results, and genomic biomarker correlates. It is hoped that this resource would permit the study of risk factors and the creation of predictive algorithms that may better identify people at risk, and lead to early intervention and prevention efforts.
  • Thumbnail Image
    Item
    First patient project: Engaging pathology through the donor dissection experience and its role in professionalism
    (Wiley, 2024-01) Robertson, Kyle A.; Organ, Jason M.; Yard, Michael; Byram, Jessica N.; Anatomy, Cell Biology and Physiology, School of Medicine
    The peer-reviewed anatomical education literature thoroughly describes the benefits and drawbacks of donor dissection. Gross anatomy laboratory environments utilizing donor dissection are generally considered to be a premier environment where students foster non-traditional discipline-independent skills (NTDIS), including the acquisition of professionalism, empathy, resilience, emotional intelligence, and situational awareness. Therefore, this IRB-approved study explored the impact of a formal humanism and pathology thread, the first patient project (FPP), on the personal and professional development of pre-professional undergraduate students in a gross anatomy dissection-based course. Five reflections from each student were collected across four cohorts (n = 74 students, 370 reflections). A post-course questionnaire collected data on student perceptions of the project. The framework method was used to analyze reflection and free response data and descriptive statistics were performed on Likert-style items using Excel. Three themes were identified to encompass the impacts of the FPP on professional development and include: Socialization (through collective dissection experience and pathology), Humanistic Qualities (respect for the donor and their history, and introspection), and Content and Skills (technical and NTDIS, anatomical knowledge). The end of course FPP survey was completed by 29 students across three cohorts (65%) and their perspectives were generally favorable regarding the promotion of respect, empathy, and humanization of their donors. This study underscores the value of incorporating humanism, pathology, and reflection, facilitated through formal curriculum for pre-professional undergraduate students. It provides evidence of the positive impact on their personal and professional development, supporting the integration of NTDIS in curricula across various disciplines.
  • Thumbnail Image
    Item
    Investigating Student Perceptions of a Dissection‐Based Undergraduate Gross Anatomy Course Using Q Methodology
    (Wiley, 2019) Byram, Jessica N.; Organ, Jason M.; Yard, Michael; Schmalz, Naomi A.; Anatomy and Cell Biology, IU School of Medicine
    The demand for upper‐level undergraduate dissection‐based anatomy courses is growing, as professional programs require more advanced anatomy training prior to matriculation. To address this need, Indiana University School of Medicine (IUSM) partnered with Indiana University‐Purdue University Indianapolis—a large, urban, life science‐focused campus nearby to IUSM—to offer an undergraduate, dissection‐based course in regional gross anatomy. Because this is a new course, a deeper post‐course evaluation of student perceptions was conducted using Q methodology. In this study, Q methodology was used to evaluate student views of the overall course structure, pre‐laboratory materials and activities, assessments, and quality of instruction. Of the 15 students in the spring semester 2018 cohort, 80% (n = 12) participated in the evaluation, and 10 of those students followed up with written explanations for their rationale in selecting the four statements with which they most strongly agreed and disagreed. The Q methodology sorted the students into one of three statistically significant groups: Motivated Dissectors (n = 6), Traditional Students (n = 3), and Inspired Learners (n = 3). Motivated Dissectors and Inspired Learners felt strongly that the course did not encourage self‐directed learning and that the pre‐laboratory materials were not adequate to prepare them for quizzes. Traditional Students, however, disagreed, having a favorable opinion of the pre‐laboratory materials, even though this group felt most strongly that the amount of material covered in the course was overwhelming. This study demonstrates the utility of Q methodology to evaluate courses to elucidate student perspectives and inform future course modifications.
  • Thumbnail Image
    Item
    Limited Approaches for Genomic Studies in Rapid Postmortem Tissue Collection
    (IntechOpen, 2023) Sandusky, George; Yard, Michael; Szymanski, Megan; Emmert , Lydia; Valadares, Vivian; Biology, School of Science
    Rapid postmortem tissue collection has been shown to have increasing use for molecular and genetic profiling. Although research on human tissue has been conducted for many years, modern molecular assays have significantly higher sensitivity and specificity than those used in the past. Higher grade tissue specimens are now required for the extraction of macromolecules as a result of this. In fact, these studies have paved the way for multiple postmortem tissue collection studies such as COVID-19, brain, skin, and small cell lung cancer. Best practices for tissue collection have also been developed by a number of professional organizations, including the National Institutes of Health Office of Biorepositories and the International Society of Biological and Environmental Repositories (ISBER). These guidelines can be used to establish procedures for tissue collection.
  • Thumbnail Image
    Item
    Neuroprotective Effect Of Thyrotropin-Releasing Hormone (TRH) Against Glutamate Toxicity In Vitro
    Yard, Michael; Kubek, Michael J.; Lahiri, Debomoy K.; Murrell, Jill Renee, 1964-
    Acute and chronic activation of both ionotropic and metabotropic glutamate (glut) receptors is implicated in many neurodegenerative disorders including AD, dementia, epilepsy, stroke and neurotrauma. TRH and glut receptors (ionotropic & metabotropic) receptors are differentially coexpressed in granule and pyramidal neurons of the hippocampus. The author shows TRH to be protective when added to cultured pituitary adenoma (GH-3) cells and neuron-like pheochromocytoma (PC12) cells either prior to, during, or after glut-induced toxicity (Endo. Soc. Abs. 01), and also shows that the possible neuroprotective mechanism may involve heterologous downregulation of the metabotropic glut receptors, using superfused hippocampal slices and noting a reduction of Gαq/11 (SFN Abs. 02). He has also demonstrated that TRH protected against glut toxicity in fetal cortical cultures (Endo. Soc. Abs. 04). To extend these studies he used 14-day cultured rat fetal hippocampal neurons (Day E17) to determine if TRH is protective against toxicity induced by specific ionotropic and metabotropic glut agonists. Neuronal viability and integrity were assessed by trypan blue exclusion and LDH release after 18 hrs following 30 min exposure to glut agonists. Ten µM dihydroxyphenylglycine (DHPG, a Group 1 receptor agonist) + 30 µM N-methyl-D-aspartate (NMDA)-induced toxicity (42% vs contr. P<0.05); whereas, concurrent and continued treatment with 10 uM but not 1uM 3Me-HTRH resulted in less neuronal death and damage (86% vs contr P<0.05; 53% vs contr. P>0.05) respectively. DHPG treatment alone (10 µM) for 30 min. was non-toxic by both criteria (90% vs contr. P<0.05). The data suggest that TRH may be a selective modulator of glut-induced toxicity.