Browsing by Author "Wright, Amy J."

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    Effects of Dietary Protein and Fiber at Breakfast on Appetite, ad Libitum Energy Intake at Lunch, and Neural Responses to Visual Food Stimuli in Overweight Adults.
    (MDPI, 2016-01) Sayer, R. Drew; Amankwaah, Akua F.; Tamer, Gregory G.; Chen, Ningning; Wright, Amy J.; Tregellas, Jason R.; Cornier, Marc-Andre; Kareken, David A.; Talavage, Thomas M.; McCrory, Megan A.; Campbell, Wayne W.; Department of Neurology, IU School of Medicine
    Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known. Fifteen overweight adults (5 female, 10 male; BMI: 27.1 ± 0.2 kg/m2; aged 26 ± 1 year) consumed four breakfast meals in a randomized crossover manner (normal protein (12 g) + normal fiber (2 g), normal protein (12 g) + high fiber (8 g), high protein (25 g) + normal fiber (2 g), high protein (25 g) + high fiber (8 g)). The amount of protein and fiber consumed at breakfast did not influence postprandial appetite or ad libitum energy intake at lunch. In the fasting-state, visual food stimuli elicited significant responses in the bilateral insula and amygdala and left orbitofrontal cortex. Contrary to our hypotheses, postprandial right insula responses were lower after consuming normal protein vs. high protein breakfasts. Postprandial responses in other a priori brain regions were not significantly influenced by protein or fiber intake at breakfast. In conclusion, these data do not support increasing dietary protein and fiber at breakfast as effective strategies for modulating neural reward processing and acute ingestive behavior in overweight adults.
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    Pilot Study of the Effects of High-Protein Meals During Hemodialysis on Intradialytic Hypotension in Patients Undergoing Maintenance Hemodialysis
    (Elsevier, 2019-03) Choi, Mun Sun; Kistler, Brandon; Wiese, Gretchen N.; Stremke, Elizabeth R.; Wright, Amy J.; Moorthi, Ranjani N.; Moe, Sharon M.; Hill Gallant, Kathleen M.; Medicine, School of Medicine
    Objective Hemodialysis (HD) patients have high protein and energy requirements, and protein-energy wasting is common and associated with poor outcomes. Eating during dialysis may improve nutritional status by counteracting the catabolic effects of hemodialysis treatment; but, eating during HD may be discouraged due to concerns of postprandial hypotension. However, little data is available to support this practice. In this study, we hypothesized that high protein meals during HD does not lead to symptomatic intradialytic hypotension events. Design A 9-week, non-randomized, parallel-arm study. Setting A single in-center HD clinic. Subjects 18 HD patients from two shifts completed the study. Patients were 62±16 years-old in age with dialysis vintage 3.4±2.6 years. Intervention The intervention group (n=9) received meals of ~30g protein and ~1/3 daily recommended intakes of sodium, potassium, phosphorus, and fluid for hemodialysis patients during dialysis for 25 consecutive HD sessions. The control group (n=9) completed all aspects of the study including a visit by study personnel but were not given meals. The 25 consecutive sessions prior to the start of the intervention/control phase were used as a baseline comparison for each patient. Main Outcome Measure Symptomatic hypotension event frequency. Results In the intervention arm, there were 19 symptomatic hypotension events in 5 patients pre-study and 18 events in 6 patients during the study. In the control arm, there were 16 events in 7 patients pre-study and 13 events in 7 patients during the study. Change in the frequency of symptomatic hypotension events from pre-study to during study was not different between groups (P=0.71). There was no effect of meals on nutritional status, but patients reported positive attitudes towards receiving meals during dialysis. Conclusion High-protein meals during HD did not increase symptomatic hypotension events. Larger, longer-term studies are needed to confirm these results and evaluate whether high-protein meals on dialysis benefit nutritional status and clinical outcomes.