Browsing by Author "Wang, Yujue"

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    Neutrophils Resist Ferroptosis and Promote Breast Cancer Metastasis through Aconitate Decarboxylase 1
    (Elsevier, 2023) Zhao, Yun; Liu, Zhongshun; Liu, Guoqiang; Zhang, Yuting; Liu, Sheng; Gan, Dailin; Chang, Wennan; Peng, Xiaoxia; Sung, Eun Suh; Gilbert, Keegan; Zhu, Yini; Wang, Xuechun; Zeng, Ziyu; Baldwin, Hope; Ren, Guanzhu; Weaver, Jessica; Huron, Anna; Mayberry, Toni; Wang, Qingfei; Wang, Yujue; Diaz-Rubio, Maria Elena; Su, Xiaoyang; Stack, M. Sharon; Zhang, Siyuan; Lu, Xuemin; Sheldon, Ryan D.; Li, Jun; Zhang, Chi; Wan, Jun; Lu, Xin; Medical and Molecular Genetics, School of Medicine
    Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance immunotherapy, yet it remains a challenge to identify therapeutic targets highly expressed and functionally essential in TINs but under-expressed in extra-tumoral neutrophils. Here, using single-cell RNA sequencing to compare TINs and circulating neutrophils in murine mammary tumor models, we identified aconitate decarboxylase 1 (Acod1) as the most upregulated metabolic enzyme in mouse TINs and validated high Acod1 expression in human TINs. Activated through the GM-CSF-JAK/STAT5-C/EBPβ pathway, Acod1 produces itaconate, which mediates Nrf2-dependent defense against ferroptosis and upholds the persistence of TINs. Acod1 ablation abates TIN infiltration, constrains metastasis (but not primary tumors), bolsters antitumor T cell immunity, and boosts the efficacy of immune checkpoint blockade. Our findings reveal how TINs escape from ferroptosis through the Acod1-dependent immunometabolism switch and establish Acod1 as a target to offset immunosuppression and improve immunotherapy against metastasis.
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    Transitioning to Adulthood: An Annotated Bibliography of the PSID-TA Publications
    (Indiana University Lilly Family School of Philanthropy, 2020-01) Herzog, Patricia Snell; Bopp, Monica; Watson, Bethany; Hall, Jessica; Sanburn, Karen; Hillier-Geisler, Megan; Fegley, Bryan; Pockette, Chris; Clark, Donna; Albritton, Brenna; Gates, Niki; Klink, Kendra; Brown, Sydney; Wang, Yujue
    This report provides an annotated bibliography of all 100 publications published to date on the Transition to Adulthood Supplement (TAS) of the Panel Study of Income Dynamics (PSID). Of these publications, 79 are articles in peer-reviewed journals, 6 are book chapters, and 15 are doctoral student dissertations. In terms of topic area, 40 publications focus on the impact of economics and socioeconomic status, another 18 study the effect of childhood and youth savings accounts, 41 study educational attainment and college-level outcomes, 32 study health and wellbeing, 20 investigate marriage and family dynamics, 31 explicitly attend to race and ethnicity, 10 study work and occupations, 7 neighborhood effects, 7 social capital and trust, 3 criminal activity, and 5 explicitly engage technology (note: since publications often engage multiple topics, these categories are not mutually-exclusive).