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Item Effectiveness of regional restrictions in reducing SARS-CoV-2 transmission during the second wave of COVID-19, Italy(Cold Spring Harbor Laboratory Press, 2021) Manica, Mattia; Guzzetta, Giorgio; Riccardo, Flavia; Valenti, Antonio; Poletti, Piero; Marziano, Valentina; Trentini, Filippo; Andrianou, Xanthi; Urdiales, Alberto Mateo; del Manso, Martina; Fabiani, Massimo; Vescio, Maria Fenicia; Spuri, Matteo; Petrone, Daniele; Bella, Antonino; Iavicoli, Sergio; Ajelli, Marco; Brusaferro, Silvio; Pezzotti, Patrizio; Merler, Stefano; Epidemiology, School of Public HealthTo counter the second COVID-19 wave, the Italian government has adopted a scheme of three sets of restrictions (coded as yellow, orange, and red) imposed on a regional basis. We estimate that milder restrictions in regions at lower risk (yellow) resulted in a transmissibility reduction of about 18%, leading to a reproduction number Rt of about 0.99. Stricter measures (orange and red) led to reductions of 34% and 45% and Rt values of about 0.89 and 0.77 respectively.