Browsing by Author "Uta, Daisuke"

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    Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway
    (Elsevier, 2023) Nunomura, Satoshi; Uta, Daisuke; Kitajima, Isao; Nanri, Yasuhiro; Matsuda, Kosuke; Ejiri, Naoko; Kitajima, Midori; Ikemitsu, Hitoshi; Koga, Misaki; Yamamoto, Sayaka; Honda, Yuko; Takedomi, Hironobu; Andoh, Tsugunobu; Conway, Simon J.; Izuhara, Kenji; Pediatrics, School of Medicine
    Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation is dominant in allergic skin inflammation, it is not fully understood how non-type 2 inflammation co-exists with type 2 inflammation or how type 2 inflammation causes itching. We have recently established the FADS mouse, a mouse model of AD. In FADS mice, either genetic disruption or pharmacological inhibition of periostin, a downstream molecule of type 2 inflammation, inhibits NF-κB activation in keratinocytes, leading to downregulating eczema, epidermal hyperplasia, and infiltration of neutrophils, without regulating the enhanced type 2 inflammation. Moreover, inhibition of periostin blocks spontaneous firing of superficial dorsal horn neurons followed by a decrease in scratching behaviors due to itching. Taken together, periostin links NF-κB-mediated inflammation with type 2 inflammation and promotes itching in allergic skin inflammation, suggesting that periostin is a promising therapeutic target for AD.