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Browsing by Author "Tsuzuki, Toyonori"
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Item Prostate cancer grading, time to go back to the future(Wiley, 2021-02) Egevad, Lars; Delahunt, Brett; Bostwick, David G.; Cheng, Liang; Evans, Andrew J.; Gianduzzo, Troy; Graefen, Markus; Hugosson, Jonas; Kench, James G.; Leite, Katia R.M.; Oxley, Jon; Sauter, Guido; Srigley, John R.; Stattin, Pär; Tsuzuki, Toyonori; Yaxley, John; Samaratunga, Hemamali; Pathology and Laboratory Medicine, School of MedicineItem Update for the practicing pathologist: The International Consultation On Urologic Disease-European association of urology consultation on bladder cancer(SpringerNature, 2015-05) Amin, Mahul B.; Smith, Steven C.; Reuter, Victor E.; Epstein, Jonathan I.; Grignon, David J.; Hansel, Donna E.; Lin, Oscar; McKenney, Jesse K.; Montironi, Rodolfo; Paner, Gladell P.; Al-Ahmadie, Hikmat A.; Algaba, Ferran; Ali, Syed; Alvarado-Cabrero, Isabel; Bubendorf, Lukas; Cheng, Liang; Cheville, John C.; Kristiansen, Glen; Cote, Richard J.; Delahunt, Brett; Eble, John N.; Genega, Elizabeth M.; Gulmann, Christian; Hartmann, Arndt; Langner, Cord; Lopez-Beltran, Antonio; Magi-Galluzzi, Cristina; Merce, Jorda; Netto, George J.; Oliva, Esther; Rao, Priya; Ro, Jae Y.; Srigley, John R.; Tickoo, Satish K.; Tsuzuki, Toyonori; Umar, Saleem A.; Van der Kwast, Theo; Young, Robert H.; Soloway, Mark S.; Department of Pathology and Laboratory Medicine, IU School of MedicineThe International Consultations on Urological Diseases are international consensus meetings, supported by the World Health Organization and the Union Internationale Contre le Cancer, which have occurred since 1981. Each consultation has the goal of convening experts to review data and provide evidence-based recommendations to improve practice. In 2012, the selected subject was bladder cancer, a disease which remains a major public health problem with little improvement in many years. The proceedings of the 2nd International Consultation on Bladder Cancer, which included a 'Pathology of Bladder Cancer Work Group,' have recently been published; herein, we provide a summary of developments and consensus relevant to the practicing pathologist. Although the published proceedings have tackled a comprehensive set of issues regarding the pathology of bladder cancer, this update summarizes the recommendations regarding selected issues for the practicing pathologist. These include guidelines for classification and grading of urothelial neoplasia, with particular emphasis on the approach to inverted lesions, the handling of incipient papillary lesions frequently seen during surveillance of bladder cancer patients, descriptions of newer variants, and terminology for urine cytology reporting.Item Utility of Pathology Imagebase for Standardization of Prostate Cancer Grading(Wiley, 2018-07) Egevad, Lars; Delahunt, Brett; Berney, Dan M.; Bostwick, David G.; Cheville, John; Comperat, Eva; Evans, Andrew J.; Fine, Samson W.; Grignon, David J.; Humphrey, Peter A.; Hörnblad, Jonas; Iczkowski, Kenneth A.; Kench, James G.; Kristiansen, Glen; Leite, Katia R.M.; Magi-Galluzzi, Cristina; McKenney, Jesse; Oxley, Jon; Pan, Chin-Chen; Samaratunga, Hemamali; Srigley, John R.; Takahashi, Hiroyuki; True, Lawrence D.; Tsuzuki, Toyonori; van der Kwast, Theo; Varma, Murali; Zhou, Ming; Clements, Mark; Pathology and Laboratory Medicine, School of MedicineAims: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62-0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at www.isupweb.org. Non-members are able to access a limited number of cases. Conclusions: It is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instances where definitions of grades need to be clarified.