Browsing by Author "Suryadevara, Vinay Kumar"

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    Low power steering electrodes within microfluidic channels for blood cancer cell separation for MRD applications
    (2015-12) Suryadevara, Vinay Kumar; Rizkalla, Maher; Farag, Sherif S.; Salama, Paul
    In this study, a novel model for manipulating cancer blood cells based on multi-stage micro channels under varied low field concepts is proposed. Steering Device approach was followed to manipulate the cancer cells based on their various differential potentials across their membranes. The proposed approach considers the size and the surface potential as well as the iso electronic structure of the cells. These research objectives emphasize the separation of the cells in the blood stream, and differentiates various blood cells and tumors for further analysis within the microfluidic channels. The dimensions of the channel sets the required electric field for manipulating the cancer cells within the channels using low electrode voltage function. The outcomes of this research may introduce a new diagnostic approach of finding the minimum residual disease (MRD) scans, early detection and analysis scans. This thesis provides a mathematical model, detailing the theory of the cell sorting device, manipulating the blood cancer cells and design of the device structure are also detailed, leading to the optimum research parameters and process. A Computer Aided Design (CAD) was used to model the multi-cell sorting lab-on-chip device, details of hardware and software were used in the simulation of the device various stages. Reverse engineering to configure the potentials for sorting mechanism needs is discussed. The thesis work also presents a comparative study of this sorting mechanism and the other commercially available devices. The practical model of the proposed research is laid out for future consideration.
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    Non-invasive photo acoustic approach for human bone diagnosis
    (Elsevier, 2016-08-03) Thella, Ashok Kumar; Rizkalla, James; Helmy, Ahdy; Suryadevara, Vinay Kumar; Salama, Paul; Rizkalla, Maher; Electrical and Computer Engineering, School of Engineering and Technology
    The existing modalities of bone diagnosis including X-ray and ultrasound may cite drawback in some cases related to health issues and penetration depth, while the ultrasound modality may lack image quality. Photo acoustic approach however, provides light energy to the acoustic wave, enabling it to activate and respond according to the propagating media (which is type of bones in this case). At the same time, a differential temperature change may result in the bio heat response, resulting from the heat absorbed across the multiple materials under study. In this work, we have demonstrated the features of using photo acoustic modality in order to non-invasively diagnose the type of human bones based on their electrical, thermal, and acoustic properties that differentiate the output response of each type. COMSOL software was utilized to combine both acoustic equations and bio heat equations, in order to study both the thermal and acoustic responses through which the differential diagnosis can be obtained. In this study, we solved both the acoustic equation and bio heat equations for four types of bones, bone (cancellous), bone (cortical), bone marrow (red), and bone marrow (yellow). 1 MHz acoustic source frequency was chosen and 105 W/m2 power source was used in the simulation. The simulation tested the dynamic response of the wave over a distance of 5 cm from each side for the source. Near 2.4 cm was detected from simulation from each side of the source with a temperature change of within 0.5 K for various types of bones, citing a promising technique for a practical model to detect the type of bones via the differential temperature as well as the acoustic was response via the multiple materials associated with the human bones (skin and blood)., The simulation results suggest that the PA technique may be applied to non-invasive diagnosis for the different types of bones, including cancerous bones. A practical model for detecting both the temperature change via IR sensors, and acoustic wave signals may be detected via sensitive pressure transducer, which is reserved for future realization.
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    Smart Unit Care for Pre Fall Detection and Prevention
    (IEEE, 2016-07) Thella, Ashok Kumar; Suryadevara, Vinay Kumar; Rizkalla, Maher; Hossain, Gahangir; Electrical and Computer Engineering, School of Engineering and Technology
    Generally falls may occur from moving or resting postures. This may include slipping from bed and fall from a sitting, or from running or walking. The pre-fall is a non-equilibrium state of human position that may lead to serious injuries, and may negatively impact the quality life condition, particularly for elders. Physical disabilities resulting from the fall incidences may lead to high costs involved with the healing process. In this work, an embedded sensor system using Arduino micro-controller was utilized to coordinate the data received from accelerometer and gyroscope. For a given threshold voltage and fall pattern, the fall decision is made by the microcontroller, citing an incoming fall. The study addresses the number of sensors to be coordinated for enhancing probability of receiving a real fall. Sensors are suggested to be placed on the human body within a belt, and safety devices at human body as well as incorporated in a smart room will be coordinated with the processor commands. Near 150 ms time frame was detected from the simulation results, suggesting a safety device to be triggered and activated for protection within this time frame. This paper discusses the research parameters such as response time for the device activation and interfacing the microcontroller to airbag switch, and means of activating the safety devices within the sharp edges in the smart unit care to minimize the impact of the fall injuries.