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Browsing by Author "Sur, Daniel"
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Item Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine(Elsevier, 2021) Kletecka-Pulker, Maria; Mondal, Himel; Wang, Dongdong; Parra, R. Gonzalo; Maigoro, Abdulkadir Yusif; Lee, Soojin; Garg, Tushar; Mulholland, Eoghan J.; Devkota, Hari Prasad; Konwar, Bikramjit; Patnaik, Sourav S.; Lordan, Ronan; Nawaz, Faisal A.; Tsagkaris, Christos; Rayan, Rehab A.; Louka, Anna Maria; De, Ronita; Badhe, Pravin; Schaden, Eva; Willschke, Harald; Maleczek, Mathias; Boyina, Hemanth Kumar; Khalid, Garba M.; Uddin, Md. Sahab; Sanusi; Khan, Johra; Odimegwu, Joy I.; Yeung, Andy Wai Kan; Akram, Faizan; Sai, Chandragiri Siva; Bucher, Sherri; Paswan, Shravan Kumar; Singla, Rajeev K.; Shen, Bairong; Di Lonardo, Sara; Tosevska, Anela; Simal-Gandara, Jesus; Zec, Manja; González-Burgos, Elena; Habijan, Marija; Battino, Maurizio; Giampieri, Francesca; Tikhonov, Aleksei; Cianciosi, Danila; Forbes-Hernandez, Tamara Y.; Quiles, José L.; Mezzetti, Bruno; Babiaka, Smith B.; Ahmed, Mosa E. O.; Piccard, Paula; Urquiza, Mágali S.; Depew, Jennifer R.; Schultz, Fabien; Sur, Daniel; Pai, Sandeep R.; Găman, Mihnea-Alexandru; Cenanovic, Merisa; Tzvetkov, Nikolay T.; Tripathi, Surya Kant; Kharat, Kiran R.; Garcia-Sosa, Alfonso T.; Sieber, Simon; Atanasov, Atanas G.; Pediatrics, School of MedicineThe open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored for five weeks for the period 20.10.2020–24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder-identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co-occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter-community were related to the coronavirus disease 2019 (COVID-19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility-promotion, which could be successfully utilized by healthcare-related open innovation platforms or initiatives.Item The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group(Springer Nature, 2021-12-01) El Bairi, Khalid; Haynes, Harry R.; Blackley, Elizabeth; Fineberg, Susan; Shear, Jeffrey; Turner, Sophia; de Freitas, Juliana Ribeiro; Sur, Daniel; Amendola, Luis Claudio; Gharib, Masoumeh; Kallala, Amine; Arun, Indu; Azmoudeh-Ardalan, Farid; Fujimoto, Luciana; Sua, Luz F.; Liu, Shi-Wei; Lien, Huang-Chun; Kirtani, Pawan; Balancin, Marcelo; El Attar, Hicham; Guleria, Prerna; Yang, Wenxian; Shash, Emad; Chen, I-Chun; Bautista, Veronica; Do Prado Moura, Jose Fernando; Rapoport, Bernardo L.; Castaneda, Carlos; Spengler, Eunice; Acosta-Haab, Gabriela; Frahm, Isabel; Sanchez, Joselyn; Castillo, Miluska; Bouchmaa, Najat; Md Zin, Reena R.; Shui, Ruohong; Onyuma, Timothy; Yang, Wentao; Husain, Zaheed; Willard-Gallo, Karen; Coosemans, An; Perez, Edith A.; Provenzano, Elena; Gonzalez Ericsson, Paula; Richardet, Eduardo; Mehrotra, Ravi; Sarancone, Sandra; Ehinger, Anna; Rimm, David L.; Bartlett, John M. S.; Viale, Giuseppe; Denkert, Carsten; Hida, Akira I.; Sotiriou, Christos; Loibl, Sibylle; Hewitt, Stephen M.; Badve, Sunil; Symmans, William Fraser; Kim, Rim S.; Pruneri, Giancarlo; Goel, Shom; Francis, Prudence A.; Inurrigarro, Gloria; Yamaguchi, Rin; Garcia-Rivello, Hernan; Horlings, Hugo; Afqir, Said; Salgado, Roberto; Adams, Sylvia; Kok, Marleen; Dieci, Maria Vittoria; Michiels, Stefan; Demaria, Sandra; Loi, Sherene; International Immuno-Oncology Biomarker Working Group; Pathology and Laboratory Medicine, School of MedicineThe advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.