Browsing by Author "Sundaram, Suneha"

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    Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
    (American College of Gastroenterology, 2020-02) Sundaram, Suneha; Vuppalanchi, Raj; Saxena, Romil; Chalasani, Naga; Medicine, School of Medicine
    Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.