Browsing by Author "Sumer, Baran D."

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses
    (Elsevier, 2019-01) Lewis, Joshua E.; Singh, Naveen; Holmila, Reetta J.; Sumer, Baran D.; Williams, Noelle S.; Furdui, Cristina M.; Kemp, Melissa L.; Boothman, David A.; Biochemistry and Molecular Biology, School of Medicine
    Nicotinamide adenine dinucleotide (NAD+) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD+ metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD+ metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD+ metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD+ metabolism, which are being used to identify novel targets in the NAD+ metabolic network for therapeutic interventions in combination with radiation therapy.