Browsing by Author "Sprague, Briana"

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    Design and baseline characteristics of the Cognitive and Aerobic Resilience for the Brain (CARB) study
    (Elsevier, 2023-08) Tam, Joyce W.; Khurshid, Kiran; Sprague, Briana; Clark, Daniel O.; Xu, Huiping; Moser, Lyndsi R.; Miller, Douglas K.; Considine, Robert; Callahan, Christopher M.; Garringer, Holly J.; Rexroth, Daniel; Unverzagt, Frederick W.; Pathology and Laboratory Medicine, School of Medicine
    Background Treatments that delay progression of cognitive impairment in older adults are of great public health significance. This manuscript outlines the protocol, recruitment, baseline characteristics, and retention for a randomized controlled trial of cognitive and aerobic physical training to improve cognition in individuals with subjective cognitive dysfunction, the “Cognitive and Aerobic Resilience for the Brain” (CARB) study. Methods Community-dwelling, older adults with self-reported memory loss were randomly assigned to receive either computer-based cognitive training, aerobic physical training, combined cognitive and physical training, or education control. Treatment was delivered 2- to 3-times per week in 45- to 90-min sessions for 12 weeks by trained facilitators videoconferencing into subject's home. Outcome assessments of were taken at the baseline, immediately following training, and 3-months after training. Results 191 subjects were randomized into the trial (mean age, 75.5 years; 68% female; 20% non-white; mean education, 15.1 years; 30% with 1+ APOE e4 allele). The sample was generally obese, hypertensive, and many were diabetic, while cognition, self-reported mood, and activities of daily living were in the normal range. There was excellent retention throughout the trial. Interventions were completed at high rates, participants found the treatments acceptable and enjoyable, and outcome assessments were completed at high rates. Conclusions This study was designed to determine the feasibility of recruiting, intervening, and documenting response to treatment in a population at risk for progressive cognitive decline. Older adults with self-reported memory loss were enrolled in high numbers and were well engaged with the intervention and outcome assessments.
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    Examining the Relationships Between Resilience, Cardiovascular Health, and Race Among US Adults
    (Oxford University Press, 2024-12-31) Sprague, Briana; Mosesso, Kelly; Medicine, School of Medicine
    Modifiable risk and resilience factors explain up to 90% of cardiovascular disease risk. These may contribute to racial cardiovascular health (CVH) disparities, but there has been limited examination of the role of resilience on CVH and disparities. Our goal was to examine (1) which risk and resilience measures were associated with CVH and (2) whether there were differences in these measures by race among a sample of US adults. Aim 1’s sample included adults aged 34-84 from the MIDUS biomarker substudy (N = 1255). Aim 2’s sample comprised of adults aged 28-84 from the MIDUS parent study (N = 4702). The primary outcome of interest was CVH, operationalized as the AHA’s Life’s Essential 8 total score, behavior, and health subscores. The hypothesized resilience measures were psychological well-being (“PWB”; assessed with Ryff and Multidimensional Personality Scale), purpose in life, mindfulness, gratitude, and optimism (MPS subscales). Of those, greater PWB (Ryff), purpose in life, and optimism correlated with better Essential 8 total score and behavioral subscore (ps <.01). Higher PWB (MPS), as well as higher gratitude, were associated with better Essential 8 behavioral scores (p <.05). Of these, PWB (MPS), gratitude, and optimism were significantly differences by race, where Black adults had significantly greater values on all measures (p <.001). Implications for future research and practice will be discussed.