Browsing by Author "Smith, Tawny"

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    Subjective cognitive impairment and its relationship to sleep impairment, anxiety severity, and depressive symptoms in individuals with bipolar disorder
    (Elsevier, 2022) Siegel-Ramsay, Jennifer E.; Wu, Bryan; Bond, Mark; Spelber, David; Chiang, Karl S.; Lanza di Scalea, Teresa; Collier, Sam J.; Smith, Tawny; Nunez, Leyna; Fuller, Ersten; Strakowski, Stephen M.; Lippard, Elizabeth; Almeida, Jorge R. C.; Psychiatry, School of Medicine
    Objectives: Individuals with bipolar disorder commonly report cognitive impairment which is associated with several psychosocial factors (e.g., mood symptoms). Within this study, we investigated the relationship between these psychosocial factors and the perception of cognitive impairment in individuals with bipolar disorder. Methods: We measured the relationship between subjective cognitive impairment and mood symptoms, quality of life, age, gender, bipolar disorder subtype, anxiety and sleep disturbance in 140 individuals with bipolar disorder with a mixed linear regression model. Our primary outcome measures were obtained via National Institute of Health (NIH)-sponsored PROMIS cognition scores. Results: Results from the model suggest that both the PROMIS Cognitive Function and Cognitive Function-Abilities scores were significantly negatively correlated with sleep disturbance and depression symptoms (p≤0.05). PROMIS Cognitive Function was also significantly negatively correlated with anxiety (p≤0.05). Limitations: Limitations of this study include the absence of a healthy control group, limited demographic diversity, and cross-sectional study design. Conclusions: Perceived cognitive impairment in individuals with bipolar disorder is associated with increased sleep disturbance, depression, and anxiety. Future studies with objective cognitive measures combined with PROMIS self-report scores might further clarify the expression of cognitive impairment in bipolar disorder.
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    The effect of resilience on bipolar mood during specialty clinic treatment
    (Elsevier, 2024) Chiang, Karl; di Scalea, Teresa Lanza; Smith, Tawny; Spelber, David; Siegel-Ramsay, Jennifer; Nemeroff, Charles B.; Strakowski, Stephen M.; Almeida, Jorge; Psychiatry, School of Medicine
    Background: Limitations in mental health resources behoove exploration of factors that may enhance treatment response. One such factor, resilience, has been minimally examined in bipolar disorder. Methods: With multi-level modeling of clinical care data, we examined associations among longitudinal measurements of resilience and mood rating trajectories in a sample of 100 individuals with bipolar disorder during 6 weeks of evidence-based pharmacotherapy and psychotherapy. Results: Individuals with high self-care subscale scores from the Resilience Questionnaire for Bipolar Disorder exhibited an improving rate of depression change -0.18 (SE = 0.04, p < .001) completing treatment with a subthreshold depression rating of 3.1 (SE = 1.39, p < .05). In contrast, treatment recipients who disagreed or were neutral towards self-care experienced worsening or no change in depression, respectively. This subscale also decreased mood elevation. Each one-point increase yielded a -0.27 (SE = 0.13 p < .05) point decrease in mania. Limitations: Resilience may develop longitudinally. In this study, it was examined during active treatment which was a relatively brief period of time. Conclusions: Higher bipolar resilience could identify individuals more likely to exhibit improvement in mood during bipolar specialty clinic treatment.