Browsing by Author "Singh, Romil"

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    COVID-19 Infection and Guillain-Barre Syndrome: A Case Series
    (Cureus, 2022-02-07) Carpenter, Kendal; Iqbal, Ayman; Singh, Romil; Deepika, Keerti; Koritala, Thoyaja; Jain, Nitesh; Alur, Ram Sanjeev; Adhikari, Ramesh; Mellekate, Vishwas S.; Neurology, School of Medicine
    The coronavirus disease 2019 (COVID-19) pandemic brought about an unprecedented time. Multiple systemic complications have been recognized with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as it can do much more than affect the respiratory system. One of the intriguing neurological complications is Guillain-Barre syndrome (GBS). We reviewed three cases in which patients presented with GBS following COVID-19 infection. All three cases had positive lumbar puncture results with albumino-cytological dissociation. Each patient was treated with plasmapheresis and improved clinically. Although an exact causal relationship between COVID-19 and GBS cannot be drawn from this case series alone, it signifies the importance of this complication. It warrants further studies to establish the causal relationship. One should have a high suspicion for acute inflammatory demyelinating polyneuropathy (AIDP) in patients presenting with acute onset of ascending weakness following COVID-19 infection.
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    Intestinal Perforation: A Rare Complication of Treatment With Bevacizumab
    (Cureus, 2021-03-24) Adhikari, Ramesh; Ghose, Medha; Tekin, Aysun; Singh, Simranjit; Singh, Romil; Medicine, School of Medicine
    Bevacizumab, a monoclonal immunoglobulin-G1 antibody directed against vascular endothelial growth factor (VEGF), inhibits angiogenesis. Gastrointestinal perforation is a serious and often fatal adverse event related to bevacizumab use. Bevacizumab is indicated in the treatment of colorectal malignancies, certain subtypes of non-small cell lung carcinoma, metastatic renal cell carcinomas, and cervical cancers. It is also indicated in the treatment of recurrent glioblastoma (GBM) in adult patients as the sole treatment agent or in combination with other antineoplastic medications. We present a case of a patient on bevacizumab currently with glioblastoma multiforme and seizures, who was previously treated with radiation treatment and temozolomide. The patient presented to the emergency room with abdominal pain, seizures and was diagnosed to have an intestinal perforation.