Browsing by Author "Simon, Jeremy M."

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    A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin*.
    (ASBMB, 2015-10-23) Simon, Jeremy M.; Parker, Joel S.; Liu, Feng; Rothbart, Scott B.; Ait-Si-Ali, Slimane; Strahl, Brian D.; Jin, Jian; Davis, Ian J.; Mosley, Amber L.; Pattenden, Samantha G.; Department of Biochemistry and Molecular Biology, IU School of Medicine
    Background: G9a-GLP lysine methyltransferases mono- and di-methylate histone H3 lysine 9 (H3K9me2).Results: Widely interspaced zinc finger (WIZ) regulates H3K9me2 levels through a mechanism that involves retention of G9a on chromatin.Conclusion: The G9a-GLP-WIZ complex has unique functions when bound to chromatin that are independent of the H3K9me2 mark.Significance: Combining pharmacologic and genetic manipulations is essential to any translational hypotheses related to G9a function.