Browsing by Author "Schutz, Anna-Lena"

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    Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers
    (Wiley, 2024) Liu, Shiwei; Park, Tamina; Krüger, Dennis M.; Pena-Centeno, Tonatiuh; Burkhardt, Susanne; Schutz, Anna-Lena; Huang, Yen-Ning; Rosewood, Thea; Chaudhuri, Soumilee; Cho, MinYoung; Risacher, Shannon L.; Wan, Yang; Shaw, Leslie M.; Sananbenesi, Farahnaz; Brodsky, Alexander S.; Lin, Honghuang; Krunic, Andre; Krzysztof Blusztajn, Jan; Saykin, Andrew J.; Delalle, Ivana; Fischer, Andre; Nho, Kwangsik; Alzheimer's Disease Neuroimaging Initiative; Radiology and Imaging Sciences, School of Medicine
    Introduction: MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis. Methods: We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis. Machine learning approaches were applied to investigate the role of miRNAs as blood biomarkers. Results: We identified nine, two, and eight miRNAs significantly associated with A/T/N positivity, respectively. We identified 271 genes targeted by amyloid-related miRNAs with estrogen signaling receptor-mediated signaling among the enriched pathways. Additionally, 220 genes targeted by neurodegeneration-related miRNAs showed enrichment in pathways including the insulin growth factor 1 pathway. The classification performance of demographic information for A/T/N positivity was increased up to 9% with the inclusion of miRNAs. Discussion: Plasma miRNAs were associated with central A/T/N biomarkers, highlighting their potential as blood biomarkers. Highlights: We performed association analysis of microRNAs (miRNAs) with amyloid/tau/neurodegeneration (A/T/N) biomarker positivity. We identified dysregulated miRNAs for A/T/N biomarker positivity. We identified Alzheimer's disease biomarker-specific/common pathways related to miRNAs. miRNAs improved the classification for A/T/N positivity by up to 9%. Our study highlights the potential of miRNAs as blood biomarkers.