Browsing by Author "Schlagenhauf, Patricia"
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Item Antibiotics in the pipeline: a literature review (2017–2020)(Springer, 2021-10-04) Al-Tawfiq, Jaffar A.; Momattin, Hisham; Al-Ali, Anfal Y.; Eljaaly, Khalid; Tirupathi, Raghavendra; Haradwala, Mohamed Bilal; Areti, Swetha; Alhumaid, Saad; Rabaan, Ali A.; Al Mutair, Abbas; Schlagenhauf, Patricia; Medicine, School of MedicineIntroduction Antimicrobial resistance (AMR) is an emerging global threat. It increases mortality and morbidity and strains healthcare systems. Health care professionals can counter the rising AMR by promoting antibiotic stewardship and facilitating new drug development. Even with the economic and scientific challenges, it is reassuring that new agents continue to be developed. Methods This review addresses new antibiotics in the pipeline. We conducted a review of the literature including Medline, Clinicaltrials.org, and relevant pharmaceutical companies for approved and in pipeline antibiotics in phase 3 or new drug application (NDA). Results We found a number of new antibiotics and reviewed their current development status, mode of action, spectra of activity, and indications for which they have been approved. The included studies from phase 3 clinical trials were mainly utilized for the treatment of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and pneumonia acquired in the healthcare settings. The number of these agents is limited against high priority organisms. The identified antibiotics were based mainly on previously known molecules or pre-existing antimicrobial agents. Conclusion There are a limited number of antibiotics against high priority organisms such as multi-drug-resistant Pseudomonas aeruginosa, and carbapenem-resistant Enterobacteriaceae. New antimicrobial agents directed against the top priority organisms as classified by the World Health Organization are urgently needed.Item Correction to: Antibiotics in the pipeline: a literature review (2017-2020)(Springer, 2022) Al‑Tawfiq, Jaffar A.; Momattin, Hisham; Al‑Ali, Anfal Y.; Eljaaly, Khalid; Tirupathi, Raghavendra; Haradwala, Mohamed Bilal; Areti, Swetha; Alhumaid, Saad; Rabaan, Ali A.; Al Mutair, Abbas; Schlagenhauf, Patricia; Medicine, School of MedicineCorrection to: Infection 10.1007/s15010-021-01709-3Item Infection risks associated with the 2022 FIFA World Cup in Qatar(Elsevier, 2022-11-22) Al-Tawfiq, Jaffar A.; Gautret, Philippe; Schlagenhauf, Patricia; Medicine, School of MedicineItem Infectious disease risks at the Rugby World Cup 2023 in France - Beware of Aedes and co!(Elsevier, 2023-09-09) Al-Tawfiq, Jaffar A.; Hedrich, Nadja; Lovey, Thibault; Gautret, Philippe; Schlagenhauf, Patricia; Medicine, School of MedicineItem Measles matter: Recent outbreaks highlight the need for catch-up vaccination in Europe and around the globe(Elsevier, 2024-03-16) Al-Tawfiq, Jaffar A.; Jain, Nityanand; Tanasov, Andrei; Schlagenhauf, Patricia; Medicine, School of MedicineItem Mpox outbreak in South Africa: A wake-up call for strengthening preparedness and response(Elsevier, 2024-07-23) Al-Tawfiq, Jaffar A.; Pan, Qiuwei; Schlagenhauf, Patricia; Medicine, School of MedicineItem The cholera challenge: How should the world respond?(Elsevier, 2022-12-23) Al-Tawfiq, Jaffar A.; Chopra, Hitesh; Dhama, Kuldeep; Sah, Ranjit; Schlagenhauf, Patricia; Memish, Ziad A.; Medicine, School of MedicineItem What is the burden of asymptomatic coronavirus infections?(Elsevier, 2023) Al-Tawfiq, Jaffar A.; Memish, Ziad A.; Altawfi, Kauthar J.; Pan, Qiuwei; Schlagenhauf, Patricia; Medicine, School of Medicine