Browsing by Author "Ren, Xiang"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Electrically conductive 3D printed Ti3C2Tx MXene-PEG composite constructs for cardiac tissue engineering
    (Elsevier, 2022) Basara, Gozde; Saeidi-Javash, Mortaza; Ren, Xiang; Bahcecioglu, Gokhan; Wyatt, Brian C.; Anasori, Babak; Zhang, Yanliang; Zorlutuna, Pinar; Mechanical and Energy Engineering, School of Engineering and Technology
    Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripotent stem cell derived cardiomyocytes (iCMs) is developed for cardiac tissue engineering applications. The constructs are fabricated by 3D printing conductive titanium carbide (Ti3C2Tx) MXene in pre-designed patterns on polyethylene glycol (PEG) hydrogels, using aerosol jet printing, at a cell-level resolution and then seeded with iCMs and cultured for one week with no signs of cytotoxicity. The results presented in this work illustrate the vital role of 3D-printed Ti3C2Tx MXene on aligning iCMs with a significant increase in MYH7, SERCA2, and TNNT2 expressions, and with an improved synchronous beating as well as conduction velocity. This study demonstrates that 3D printed Ti3C2Tx MXene can potentially be used to create physiologically relevant cardiac patches for the treatment of MI.
  • Thumbnail Image
    Item
    HARDWARE DESIGNING OF A SMART ROBOTIC PET
    (Office of the Vice Chancellor for Research, 2011-04-08) Yang, Heng; Ren, Xiang; Terry, Isaac; Beigzadeh, Ilnaz; Tunc, Azize; Du, Eliza; Orono, Peter; Long, Michael
    Human have dreamed to have robot since ancient time. Aristotle wrote of the idea in 322 BCE as a perfect measure to bring equality to civilization by removing the need for labor. Modern robots have permeated the very way of life in all aspects of human activity, particularly after the creation of the microprocessor. In this poster, the process of developing the hardware of an autonomously movable robotic pet will be introduced. Four steps were followed when designing the hardware for robotic pet – 1) identify the need, 2) research the need, 3) develop possible solution and select best solution, 4) test and evaluate the solution, and 4) optimize the design. In particular, three major factors need to be taken in consideration—structure of the base, driving system, and power required. To ensure an efficient and economic design, all possible solutions for driving system and structure are compared by matrix chart. The power and torque needed is calculated based on the weight and speed of the robotic pet. After identify the driving system and chassis, CAD software is used to sketch the blueprint for the hardware. In addition, we need to do face recognition using the camera mounted on the robot. However, the motion of the robot may severely degrade the image and signal quality. To mitigate noise effect, special effort is made such as using special type of wheel to decrease shock of the robot.