Browsing by Author "Rahnama-Moghadam, Sahand"

Now showing 1 - 10 of 21
  • Thumbnail Image
    Item
    A review of drug-induced liver injury with rash, eosinophilia, and systemic symptoms (DRESS) syndrome: Cutaneous manifestations, clinical features, and management
    (Wolters Kluwer, 2024-05-31) Arora, Nitin; Chalasani, Naga; Rahnama-Moghadam, Sahand; Medicine, School of Medicine
  • Thumbnail Image
    Item
    Apixaban-induced cutaneous hypersensitivity: a case series with evidence of cross-reactivity
    (University of California, 2020) Isaq, Nasro A.; Vinson, Whitney M.; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
  • Thumbnail Image
    Item
    Characterization of medical malpractice lawsuits relating to dermatologic emergencies in the inpatient and emergency setting
    (Elsevier, 2020) Rumancik, Brad; Keele, Benjamin J.; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
  • Thumbnail Image
    Item
    Circumscribed Palmar Hypokeratosis With Superimposed Actinic Keratosis
    (Springer Nature, 2023-01-30) Auckerman, Erica; Rao, Megana; Samiei, Azadeh; Bell, Marcia C.; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
    A man in his late 70s with a history of psoriasis and non-melanoma skin cancer presented with a progressive rash on his right thenar eminence. He first noticed it about one year ago. He denied any pruritus in the affected region but did note some overlying skin breakdown. He had used topical betamethasone and calcipotriene cream in the past with minimal improvement. Physical examination revealed a pink atrophic plaque with linear hyperkeratotic borders and central fissuring on the right thenar eminence extending into the first webspace. A shave biopsy revealed hypokeratosis with a rim of surrounding hyperkeratosis and associated parakeratosis, basal keratinocyte atypia, and lichenoid inflammation. These histopathological features were consistent with circumscribed palmar hypokeratosis and central actinic keratosis. Circumscribed palmar hypokeratosis is often considered a benign entity, but there have been reports suggesting an association with premalignancy. The decision was made to treat with 5-fluorouracil and calcipotriene cream twice daily for six weeks. At his two-month follow-up, he endorsed a robust reaction, which was further suggestive of premalignant change. He had a near-complete resolution of the rash. This case features circumscribed palmar hypokeratosis and suggests a novel treatment option for patients who develop concomitant actinic keratosis.
  • Thumbnail Image
    Item
    Cutaneous collagenous vasculopathy: development after coronary artery bypass surgery
    (eScholarship Publishing, University of California, 2018) Rahnama-Moghadam, Sahand; Burgin, Callie; Gilbert, Juliana; Warren, Simon; Dermatology, School of Medicine
    Cutaneous collagenous vasculopathy (CCV) is a rare benign microangiopathy of the superficial dermal vessels. Clinically, it is characterized by widespread, asymptomatic development of cutaneous telangiectasia in the absence of systemic symptoms. Morphologically, it most resembles generalized essential telangiectasia and other telangiectatic syndromes such as telangiectasia macularis eruptiva perstans (TMEP), ataxia telangiectasia, and hereditary hemorrhagic telangiectasia. It is distinctive in its histology, showing characteristic dilated thick-walled blood vessels in the superficial dermis. The thickened walls of these superficial dermal blood vessels demonstrate reduplication of the basement membrane on PAS staining. We report a 63-year-old man with CCV with this condition for 20 years, starting in 1996. He was diagnosed in the past as having essential telangiectasia. The development of the telangectasias occurred after coronary artery bypass grafting, also performed in 1996. This case not only demonstrates the characteristic clinical and histologic findings, but also suggests a possible mechanism. Moreover, it illustrates that cases of generalized essential telangiectasia may in fact be CCV that are misclassified.
  • Thumbnail Image
    Item
    Dermatologic manifestations of vascular access steal syndrome
    (Our Dermatology Online, 2020) Hekman, Daniel; Burton, Kyle; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
  • Thumbnail Image
    Item
    Describing Hidradenitis Suppurativa Misinformation Diffusion Among Facebook Users: A Content Analysis
    (Matrix Medical Communications, 2023) Méndez, Alejandra; Rao, Megana; Rahnama-Moghadam, Sahand; Gomaa, Basma; Walsh-Buhi, Eric R.; Dermatology, School of Medicine
  • Thumbnail Image
    Item
    Diet-induced Pigmented Purpuric Dermatosis Confirmed with a Rechallenge Response
    (Cureus, Inc., 2019-07-29) Li, Wendy; Reedy, Matthew; Alomari, Ahmed K.; Rahnama-Moghadam, Sahand; Medicine, School of Medicine
    The pigmented purpuric dermatoses (PPDs) are a group of chronic cutaneous eruptions characterized by non-blanching and non-palpable purpuric lesions. Their etiology is not completely understood, although dietary exposures have been implicated in a few case reports. We describe a recurring case of diet-induced PPD in a 73-year-old Caucasian male following the ingestion of tomato-based products on two separate occasions, one year apart. On physical examination, he demonstrated numerous 1-2 mm red/brown, non-blanching, petechial macules scattered on the bilateral anterior lower legs, thighs, trunk, arms, hands, and feet with facial sparing. Histopathologic examination revealed the classic perivascular lymphocytic infiltrate with red blood cell extravasation seen in PPD. Mirroring his first episode, the patient saw a complete resolution of his rashes with careful avoidance of tomato-based products and required no other interventions. This represents a rare case of diet-induced PPD confirmed with a rechallenge response and suggests that acute or recurrent cases of PPD may be a result of a hypersensitivity reaction.
  • Thumbnail Image
    Item
    Drug Reaction With Eosinophilia and Systemic Symptoms to Vancomycin-Laden Cement Space: A Case Report
    (Springer Nature, 2025-01-03) Chalasani, Sai; Mannam, Harshita; Alomari, Ahmed K.; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
    Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse drug reaction mediated by a complex immune response. Vancomycin is a known cause of DRESS, and cases are often attributed to intravenous exposure. Vancomycin-laden bone cements deliver high concentrations of the drug locally with low to undetectable systemic levels. Despite trace systemic concentrations, cement spacers have been reported to cause systemic reactions ranging from organ failure to diffuse cutaneous eruptions. A patient receiving intravenous (IV) and local vancomycin, via bone cement, experienced symptom resolution only after the vancomycin-eluting bone cement was removed, which was done after the IV vancomycin had been stopped. This suggests that the vancomycin eluted from the local bone cement may be sufficient to maintain the immune response mediating DRESS syndrome. In patients who experience persistent symptoms despite discontinuing systemic drug exposure, clinicians should consider eliminating all sources of the causative drug.
  • Thumbnail Image
    Item
    Erythema annulare centrifugum-type eruption in a patient undergoing cancer vaccine immunotherapy
    (Dermatology Online Journal, 2018-10-15) Tadros, Joseph; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
    Sipuleucel-T is a cellular immunotherapy approved for the treatment of metastatic castration-resistant prostate cancer. We report a patient developing an immune related adverse effect from sipuleucel-T drug-induced erythema annulare centrifugum-like eruption. A brief review of the mechanism and implications of this eruption are also included.