Browsing by Author "Paul, Robert"

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    Correlates of Sleep Health among Older-Age People with and without HIV in Uganda
    (Springer, 2024) Yoo-Jeong, Moka; Ratnayake, Aneeka; Tong, Yao; Tsai, Alexander C.; Paul, Robert; Reynolds, Zahra; Ritchie, Christine S.; Seeley, Janet; Hoeppner, Susanne S.; Atwiine, Flavia; Okello, Samson; Nakasujja, Noeline; Saylor, Deanna; Greene, Meredith; Asiimwe, Stephen; Tindimwebwa, Edna; Tanner, Jeremy; Olivieri-Mui, Brianne; Siedner, Mark J.; Medicine, School of Medicine
    There is a growing population of older people with HIV (PWH) in Uganda. Sleep problems disproportionately affect older people and PWH. This study aimed to estimate correlates of sleep health among older Ugandans (aged ≥ 50 years) with and without HIV, using data from the Quality of Life and Aging with HIV in Rural Uganda Study. We used the Pittsburgh Sleep Quality Index to assess sleep quality, duration, and efficiency. We fitted multivariable linear and logistic regression models to estimate the associations between sleep outcomes and variables selected based on the Senescent Sleep Model: age, HIV serostatus, loneliness, urbanicity, symptoms of depression and anxiety, and perceived stress. Of 556 participants, 271 were PWH and 285 were people without HIV (PWoH). There were no statistically significant differences in sleep outcomes by HIV serostatus. Of the total sample, most reported very good (32.79%) or fairly good sleep quality (49.37%). The mean sleep duration was 6.46 h (SD = 1.74). The mean sleep efficiency was 73.98% (SD = 19.52%) with 36.69% having optimal (≥ 85%) sleep efficiency. A positive depression screen was associated with worse sleep quality (adjusted odds ratio [aOR] = 0.21; 95% CI [0.12, 0.36]), shorter sleep duration (b=-0.44; 95% CI [-0.60, -0.28]), and worse sleep efficiency (aOR = 0.51; 95% CI[0.31, 0.83]). Interventions targeting depression may improve sleep among older Ugandans, independent of HIV serostatus. Longitudinal studies are needed to determine the potential bidirectionality of this relationship and elucidate pathways to support sleep health among older Ugandans.
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    HIV, Social Networks, and Loneliness among Older Adults in Uganda
    (Springer, 2024) Quach, Lien T.; Ritchie, Christine S.; Reynolds, Zahra; Paul, Robert; Seeley, Janet; Tong, Yao; Hoeppner, Susanne; Okello, Samson; Nakasujja, Noeline; Olivieri-Mui, Brianne; Saylor, Deanna; Greene, Meredith; Asiimwe, Stephen; Tindimwebwa, Edna; Atwiine, Flavia; Sentongo, Ruth; Siedner, Mark J.; Tsai, Alexander C.; Medicine, School of Medicine
    Loneliness among older adults has been identified as a major public health problem. Yet little is known about loneliness, or the potential role of social networks in explaining loneliness, among older people with HIV (PWH) in sub-Saharan Africa, where 70% of PWH reside. To explore this issue, we analyzed data from 599 participants enrolled in the Quality of Life and Ageing with HIV in Rural Uganda study, including older adults with HIV in ambulatory care and a comparator group of people without HIV of similar age and gender. The 3-item UCLA Loneliness Scale was used to measure loneliness, and HIV status was the primary explanatory variable. The study found no statistically significant correlation between loneliness and HIV status. However, individuals with HIV had smaller households, less physical and financial support, and were less socially integrated compared to those without HIV. In multivariable logistic regressions, loneliness was more likely among individuals who lived alone (aOR:3.38, 95% CI:1.47-7.76) and less likely among those who were married (aOR:0.34, 95% CI:0.22-0.53) and had a higher level of social integration (aOR:0.86, 95% CI: 0.79-0.92). Despite having smaller social networks and less support, older adults with HIV had similar levels of loneliness as those without HIV, which may be attributed to resiliency and access to HIV-related health services among individuals with HIV. Nonetheless, further research is necessary to better understand the mechanisms involved.
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    Prevalence and Correlates of Frailty Among Older People With and Without HIV in Rural Uganda
    (Wolters Kluwer, 2024) Mbabazi, Phoebe; Chen, Geoffrey; Ritchie, Christine S.; Tsai, Alexander C.; Reynolds, Zahra; Paul, Robert; Seeley, Janet; Tong, Yao; Hoeppner, Susanne; Okello, Samson; Nakasujja, Noeline; Olivieri-Mui, Brianne; Tanner, Jeremy A.; Saylor, Deanna; Asiimwe, Stephen; Siedner, Mark J.; Greene, Meredith; Medicine, School of Medicine
    Background: The relationship between HIV and frailty, a predictor of poor outcomes in the face of stressors, remains unknown in older people in sub-Saharan Africa. Methods: We analyzed data from the Quality of Life and Ageing with HIV in Rural Uganda cohort study to estimate the prevalence and correlates of frailty among older people with HIV (PWH) on long-term antiretroviral therapy and among age- and sex-matched HIV-uninfected comparators. Frailty was defined as a self-report of 3 or 4 (and pre-frailty as 1 or 2) of the following phenotypic variables: weight loss, exhaustion, low activity, and slowness. We estimated the prevalence of frailty and prefrailty and fitted logistic regression models to estimate the association between HIV and frailty, adjusting for sociodemographic factors, depression, and other comorbidities. Results: We enrolled 599 participants (49% women) with a mean age of 58 years. PWH had a similar prevalence of frailty (8.1% vs. 10.9%, P = 0.24) but a lower prevalence of prefrailty (54.2% vs. 63.2%, P = 0.03) compared with their HIV-uninfected comparators. In multivariable regression models, people with depression [adjusted odds ratio (AOR) 7.52 (95% CI: 3.67 to 15.40), P < 0.001] and those with ≥1 comorbidities [AOR 3.15 (95% CI: 1.71 to 3.82), P < 0.001] were more likely to be frail. HIV serostatus was not significantly associated with frailty [AOR 0.71 (95% CI: 0.37 to 1.34), P = 0.29]. Conclusions: Older PWH had a similar prevalence of frailty as those without HIV. These findings call for additional study of the factors that contribute to the robustness of older PWH in sub-Saharan Africa.