Browsing by Author "Park, Shinyoung"

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    Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models
    (MDPI, 2019-03-25) Ganesan, Palanivel; Kim, Byungwook; Ramalaingam, Prakash; Karthivashan, Govindarajan; Revuri, Vishnu; Park, Shinyoung; Kim, Joon Soo; Ko, Young Tag; Choi, Dong-Kug; Medical and Molecular Genetics, School of Medicine
    Curcumin, which is a potential antineuroinflammatory and neuroprotective compound, exhibits poor bioavailability in brain cells due to its difficulty in crossing the blood⁻brain barrier and its rapid metabolism during circulation, which decreases its efficacy in treating chronic neuroinflammatory diseases in the central nervous system. The bioavailability and potential of curcumin can be improved by using a nanodelivery system, which includes solid lipid nanoparticles. Curcumin-loaded solid lipid nanoparticles (SLCN) were efficiently developed to have a particle size of about 86 nm and do not exhibit any toxicity in the endothelial brain cells. Furthermore, the curcumin-loaded solid lipid nanoparticles (SLCN) were studied to assess their efficacy in BV-2 microglial cells against LPS-induced neuroinflammation. The SLCN showed a higher inhibition of nitric oxide (NO) production compared to conventional curcumin in a dose-dependent manner. Similarly, the mRNA and proinflammatory cytokine levels were also reduced in a dose-dependent manner when compared to those with free curcumin. Thus, SLCN could be a potential delivery system for curcumin to treat microglia-mediated neuroinflammation.
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    Youth Philanthropy: Studying Outcomes of Community Engagement
    (Lilly Family School of Philanthropy, 2024-10) Herzog, Patricia Snell; Penman, Natalie; Park, Shinyoung; Lambert, Minette; Ortiz, Lexi; August, Jeffrey; Morgan, Anna; Carey, M’lila
    This report shares results from a study of youth philanthropy programs designed to increase community engagement. The study is designed to answer this research question: Does participating in a youth philanthropy program foster positive outcomes for young people? Data are from a youth philanthropy program hosted within 12 community organizations in 7 US states. The program is two years in duration: youth participate as juniors and seniors in high school. Data were collected through surveys with graduating youth who had completed both years of the program (n=180). Findings indicate that the program “works” in fostering engagement in philanthropic activities, gaining prosocial orientations, and having rewarding program experiences. When available, youth outcomes from program participants are compared to national or global data on comparable measures to assess whether youth in this program appear to be participating in philanthropic activities at rates greater than average. Results show that youth participants are high on philanthropic activities and prosocial orientations, and their rates are 30-50% higher than comparable rates. Additionally, youth demonstrate positive growth in targeted philanthropic learning and skills, and youth participants gain a greater network of engaged peers and supportive mentors. The implication is that this youth philanthropy program is successful in fostering positive youth development.