IU Indianapolis ScholarWorks :: Browsing by Author "Park, Choongseok"

Browsing by Author "Park, Choongseok"

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25th Annual Computational Neuroscience Meeting: CNS-2016
(BioMed Central, 2016-08-18) Sharpee, Tatyana O.; Destexhe, Alain; Kawato, Mitsuo; Sekulić, Vladisla; Skinner, Frances K.; Wójcik, Daniel K.; Chintaluri, Chaitanya; Cserpán, Dorottya; Somogyvári, Zoltán; Kim, Jae Kyoung; Kilpatrick, Zachary P.; Bennett, Matthew R.; Josić, Kresimir; Elices, Irene; Arroyo, David; Levi, Rafael; Rodriguez, Francisco B.; Varona, Pablo; Hwang, Eunjin; Kim, Bowon; Han, Hio-Been; Kim, Tae; McKenna, James T.; Brown, Ritchie E.; McCarley, Robert W.; Choi, Jee Hyun; Rankin, James; Popp, Pamela Osborn; Rinzel, John; Tabas, Alejandro; Rupp, André; Balaguer‑Ballester, Emili; Maturana, Matias I.; Grayden, David B.; Cloherty, Shaun L.; Kameneva, Tatiana; Ibbotson, Michael R.; Meffin, Hamish; Koren, Veronika; Lochmann, Timm; Dragoi, Valentin; Obermayer, Klaus; Psarrou, Maria; Schilstra, Maria; Davey, Neil; Ju, Huiwen; Hines, Michael L.; Chen, Liang; Kim, Jimin; Leahy, Will; Shlizerman, Eli; Birgolias, Justas; Gerkin, Richard C.; Crook, Sharon M.; Viriyopase, Atthaphon; Memmeshei, Raol-Martin; Dabaghian, Yuri; DeVuti, Justin; Perotti, Luca; Kim, Ammo J.; Fenk, Lisa M.; Lyu, Cheng; Malmon, Gabby; Zhao, Chang; Widmer, Yves; Sprecher, Simon; Halnes, Geir; Tuomo, Maki-Martun; Keller, Daniel; Petterson, Klas H.; Andreassen, Ole A.; Elnevoll, Gaute T.; Yamada, Yasnori; Steyn-Ross, Moira L.; Steyn-Ross, D. Alistair; Meijas, Jorge F.; Murray, John D.; Kennedy, Henry; Kruscha, Alexandra; Grewe, Jan; Lidner, Benjamin; Badel, Laurent; Kasumi, Ohta; Tsuchimoto, Yoshiko; Kazama, Hokto; Kahng, B.; Tam, Nicoladie D.; Pollonini, Luca; Zouridakis, George; Soh, Jaehyun; Kim, DaeEun; Yoo, Minsu; Palmer, S.E.; Culmone, Viviana; Bojak, Ingo; Ferrario, Andrea; Merriosn-Hort, Robert; Borisyuk, Roman; Kim, Chang Sub; Tezuka, Taro; Joo, Pangyu; Young-Ah, Rho; Burton, Shawn D.; Bard, G.; Marsalek, Petr; Kim, Hoon-Hee; Moon, Seok-hun; Lee, Do-won; Molkov, Yaroslav I.; Hamade, Khaldoun; Teka, Wondimu; Barnett, William H.; Kim, Taegyo; Markin, Sergey; Rybak, Ilya A.; Forrow, Csaba; Demutz, Harald; Demkó, László; Vörös, János; Dabaghian, Yuri; Babichev, Andrey; Huang, Haiping; Metzner, Christoph; Schwikard, Achim; Zurowski, Bartosz; Roach, James P.; Sander, Leonard M.; Zochowski, Michal R.; Skilling, Quinton M.; Ognjanovski, Nicolette; Aton, Sara J.; Zochowski, Michal; Wang, Sheng-Ju; Ouyang, Guang; Zhang, Mingsha; Wong, Michael; Zhou, Changsong; Robinson, Peter A.; Sanz-Leon, Paula; Drysdale, Peter M.; Fung, Felix; Abeysuriya, Romesh G.; Rennle, Chris J.; Zhao, Xuelong; Choe, Yoonsuck; Yang, Huei-Fang; Mi, Yuanyuan; Lin, Xiahoan; Wu, Si; Liedtke, Joscha; Schottdorf, Manual; Wolf, Fred; Yamamura, Yorkio; Wickens, Jeffery R.; Rumbell, Timothy; Ramsey, Julia; Reyes, Amy; Draguljić, Daniel; Hof, Patrick R.; Luebke, Jennifer; Weaver, Christina M.; He, Hu; Yang, Xu; Ma, Hailin; Xu, Zhiheng; Wang, Yuzhe; Baek, Kwangyeol; Morris, Laurel S.; Kundu, Prantik; Voon, Valerie; Agnes, Everton J.; Vogels, Tim P.; Giese, Martin; Kuravi, Pradeep; Vogels, Rufin; Seeholzer, Alexander; Podlaski, William; Ranjan, Rajnish; Vogels, Tim; Torres, Joaquin J.; Baroni, Fabiano; Latorre, Roberto; Varona, Pablo; Gips, Bart; Lowet, Eric; Roberts, Mark J.; de Weerd, Peter; Jensen, Ole; van der Eerden, Jan; Goodarzinic, Abdorreza; Niry, Mohammad; Valizadeh, Alireza; Pariz, Aref; Parsi, Shervin S.; Valizadeh, Alireza; Warburton, Julia M.; Marucci, Lucia; Tamagnini, Francesco; Brown, John; Tsaneva‑Atanasova, Krasimira; Kleberg, Florence I.; Triesch, Jochen; Moezzi, Bahar; Iannella, Nicolangelo; Schaworonkow, Natalie; Plogmacher, Lukas; Goldsworthy, Mitchell R.; Hordacre, Brenton; McDonnell, Mark D.; Ridding, Michael C.; Trisch, Jochen; Zaptocky, Martin; Smit, Daniel; Fouquet, Coralie; Trembleau, Alain; Dasgupta, Sakyasingha; Nishikawa, Isao; Aihara, Kazuyuki; Toyoizumi, Taro; Robb, Daniel T.; Mellen, Nick; Toporikova, Natalia; Tang, Rongxiang; Tang, Yi-Yuan; Kiser, Seth A.; Howard Jr., James H.; Tang, Yi-Yuan; Goncharenko, Julia; Davey, Neil; Schilstra, Marla; Steuber, Volker; Voronenko, Sergej O.; Linder, Benjamin; Ahamed, Tosif; Stephens, Greg; Yger, Pierre; Lefebvre, Baptiste; Spampinato, Giulia Lia Beatrice; Esposito, Elric; Stimberg, Marcel; Marre, Olivier; Choi, Hansol; Song, Min-Ho; Chung, SueYeon; Lee, Dan D.; Sompolinsky, Haim; Phillips, Ryan S.; Smith, Jeffrey; Chatzikalymniou, Alexandra Pierri; Ferguson, Katie; Skinner, Frances K.; Gajic, N. Alex Cayco; Clopath, Claudia; Silver, R. Angus; Gleeson, Padraig; Marin, Boris; Sadeh, Sadra; Quintana, Adrian; Cantarelli, Matteo; Dura‑Bernal, Salvador; Lytton, William W.; Davison, Andrew; Silver, Angus; Li, Luozheng; Zhang, Wenhao; Mi, Yuanyuan; Wang, Dahui; Wu, Sl; Song, Youngjo; Park, Sol; Choi, Ilhwan; Jeong, Jaeseung; Shin, Hee‑sup; Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric; Huh, Dongsung; Sejnowski, Terrence J.; Vogt, Simon M.; Kumar, Arvind; Schmidt, Robert; Werdt, Stephen Van; Schiff, Steven J.; Veale, Richard; Scheutz, Matthias; Lee, Sang Wan; Gallinaro, Júlia; Rotter, Stefan; Sanz‑Leon, Paula; Robinson, Peter A.; Rubchinsky, Leonid L.; Cheung, Chung Ching; Ratnadurai‑Giridharan, Shivakeshavan; Shomali, Safura Rashid; Ahmadabadi, Majid Nili; Shimazaki, Hideaki; Rasuli, Nader; Zhao, Xiaochen; Rasch, Malte J.; Witting, Jens; Priesemann, Viola; Levina, Anna; Priesemann, Viola; Lizler, Joseph T.; Spinney, Richard E.; Rubinov, Mikail; Wibral, Michael; Bak, Ji Hyun; Pillow, Jonathan; Zaho, Yuan; Park, Memming; Kang, Jiyoung; Park, Hae‑Jeong; Jang, Jaeson; Paik, Se-Bum; Choi, Woochul; Lee, Changju; Jang, Jaeson; Paik, Se‑Bum; Song, Min; Lee, Hyeonsu; Yilmaz, Ergin; Baysal, Velt; Ozer, Mahmut; Koren, Veronika; Obermayer, Klaus; Saska, Daniel; Nowotny, Thomas; Chan, Ho Ka; Diamond, Alan; Hermann, Christoph S.; Murray, Micha M.; Ionta, Silvlo; Hutt, Axel; Lefebvre, Jérémie; Weidel, Philipp; Duarte, Renato; Morrison, Abigail; Iyer, Ramakrishnan; Mihalas, Stefan; Petrovici, Mihai A.; Leng, Luziwei; Breitwieser, Oliver; Stöckel, David; Bytschok, Ilja; Martel, Roman; Bill, Johannes; Schemmel, Johannes; Meier, Karlheinz; Esler, Timothy B.; Burkitt, Anthony N.; Grayden, David B.; Kerr, Robert R.; Tahayori, Bahman; Meffin, Hamish; Moezzi, Bahar; Iannella, Nicolangelo; McDonnell, Mark D.; Nolte, Max; Reimann, Michael W.; Muler, Eilif; Markram, Henry; Parziale, Antonio; Senatore, Rosa; Marcelli, Angelo; Maouene, M.; Skiker, K.; Neymotin, Samuel A.; Dura‑Bernal, Salvador; Seidenstein, Alexandra; Lakatos, Peter; Sanger, Terence D.; Lytton, William W.; Dura‑Bernal, Salvador; Menzies, Rosemary J.; McLauchlan, Campbell; van Albada, Sacha J.; Kedziora, David J.; Neymotin, Samuel; Kerr, Cliff C.; Ryu, Juhyoung; Lee, Sang-Hun; Lee, Joonwon; Lee, Hyang Jung; Lim, Daeseob; Lee, Jung H.; Wang, Jisung; Lee, Heonsoo; Jung, Nam; Quang, Le Anh; Maeng, Seung Eu; Lee, Tae Ho; Lee, Jae Woo; Park, Chang-hyun; Ahn, Sora; Moon, Jangsup; Choi, Yun Seo; Kim, Juhee; Jun, Sang Beom; Lee, Seungjun; Lee, Hyang Woon; Jo, Sumin; Jun, Eunji; Yu, Suin; Goetze, Felix; Lai, Pik‑Yin; Kwag, Jeehyun; Liang, Guangsheng; Jang, Hyun Jae; Filipovi, Marko; Reig, Ramon; Aertsen, Ad; Silberberg, Gilad; Kumar, Arvind; Bachmann, Claudia; Buttler, Simone; Jacobs, Heidi; Dillen, Kim; Fink, Gereon R.; Kukolja, Juraj; Kepple, Daniel; Giaffar, Hamza; Rinberg, Dima; Shea, Steven; Koulakov, Alex; Bahuguna, Jyotika; Tetzlaff, Tom; Kotaleski, Jeanette Hellgren; Kunze, Tim; Peterson, Andre; Knösche, Thomas; Kim, Minjung; Kim, Hojeong; Park, Ji Sung; Yeon, Ji Won; Kim, Sung-Phil; Lee, Chungho; Kim, Sung-Phil; Spiegler, Andreas; Petkoski, Spase; Palva, Matias J.; Jirsa, Viktor K.; Saggio, Maria L.; Siep, Silvan F.; Stacey, William C.; Bernard, Christophe; Choung, Oh‑hyeon; Jeong, Yong; Lee, Yong‑il; Jeong, Jaesung; Kim, Su Hyun; Lee, Jeungmin; Kwon, Jaehyung; Kralik, Jerald D.; Hwang, Dong‑Uk; Park, Sang-Min; Kim, Seongkyun; Kim, Hyoungkyu; Lim, Sewoong; Yoon, Sangsup; Park, Choongseok; Miller, Thomas; Clements, Katie; Hye Jr., Eoon; Issa, Fadi A.; Baek, JeongHun; Oba, Shigeyuki; Yoshimoto, Junichiro; Doya, Kenji; Ishii, Shin; Mosqueiro, Thiago S; Strube‑Bloss, Martin F.; Smith, Brian; Huerta, Ramon; Hadrava, Michal; Hlinka, Jaroslav; Bos, Hannah; Helias, Moritz; Welzig, Charles M.; Harper, Zachary J.; Kim, Won Sup; Shin, In-Seob; Baek, Hyeon-Man; Han, Seung Kee; Richter, René; Vitay, Julien; Beuth, Frederick; Hamker, Fred H.; Kameneva, Tatiana; Graham, Bruce P.; Kale, Penelope J.; Gollo, Leonardo L.; Stern, Merav; Abbott, L.F.; Fedorov, Leonid A.; Giese, Martin A.; Ardestani, Mohammad Hovaidi; Giese, Martin; Chakravarthy, V.Srinivasa; Chhabria, Karishma; Philips, Ryan T.; Ardestani, Mohammad Hovaidi; Faraji, Mohammad Java; Preuschoff, Kerstin; Gerstner, Wulfram; Briaire`, Jeroen J.; Kalkman, Randy K.; Frijns, Johan H. M.; Lee, Won Hee; Frangou, Sophia; Fulcher, Ben D.; Tran, Patricia H. P.; Fornito, Alex; Gliske, Stephen V.; Stacey, William C.; Holman, Katherine A.; Fink, Christian G.; Kim, Jinseop; Mu, Shang; Briggman, Kevin L; Seung, H. Sebastian; Wegener, Detlef; Bohnenkamp, Lisa; Ernst, Udo A.; Mäki‑Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Dale, Anders M.; Andreassen, Ole A.; Einevoll, Gaute T.; Hagen, Espen; Lines, Glenn T.; Edwards, Andy; Tveito, Aslak; Senk, Johanna; van Albada, Sacha J; Diesmann, Markus; Schmidt, Maximilian; Bakker, Rembrandt; Shen, Kelly; Bezgin`, Gleb; Hilgetag`, Claus‑Christian; Sun, Haoqi; Sourina, Olga; Huang, Guang-Bin; Klanner, Felix; Denk, Cornelia; Glomb, Katharina; Ponce‑Alvarez, Adrián; Gilson, Matthieu; Ritter, Petra; Deco, Gustavo; Witek, Maria A. G.; Clarke, Eric F.; Hansen, Mads; Wallentin, Mikkel; Kringelbach, Morten L.; Vuust, Peter; Klingbeil, Guido; Schutter, Erik De; Chen, Weiliang; Hong, Sungho; Takashima, Akira; Zamora, Criseida; Gallimore, Andrew R.; Karoly, Philippa J.; Freestone, Dean R.; Soundry, Daniel; Kuhlmann, Levin; Paninski, Liam; Cook, Mark; Lee, Jaejin; Fishman, Yonatan I.; Cohen, Yale E.; Cocchi, Luca; Sweeney, Yann; Lee, Soohyun; Jung, Woo-Sung; Kim, Bowon; Kim, Youngsoo; Jung, Younginha; Rankin, James; Chavane, Frédéric; Soman, Karthik; Muralidharan, Vignesh; Shivkumar, Sabyasach; Mandall, Alekhya; Priyadharsini, B. Praga; Mehta, Hima; Brinkman, Braden A.; Kekona, Tyler; Rieke, Fred; Shea‑Brown, Eric; Buice, Michael; Pittà, Maurizio De; Berry, Hugues; Brunel, Nicolas; Breakspear, Michael; Marsat, Gary; Drew, Jordan; Chapman, Phillip D.; Daly, Kevin C.; Bradley, Samual P.; Seo, Sat Byul; Su, Jianzhong; Kavalali, Enge T.; Blackwell, Justin; Shiau, LieJune; Buhry, Laure; Basnayake, Kanishka; Lee, Sue-Hyun; Levy, Brandon A.; Baker, Chris I.; Leleu, Timothée; Aihara, Kazuyuki; Department of Mathematical Sciences, School of Science
A Closed-Loop Model of the Respiratory System: Focus on Hypercapnia and Active Expiration
(2014-10) Molkov, Yaroslav I; Shevtsova, Natalia A; Park, Choongseok; Ben-Tal, Alona; Smith, Jeffrey C; Rubin, Jonathan E; Rybak, Ilya A
Breathing is a vital process providing the exchange of gases between the lungs and atmosphere. During quiet breathing, pumping air from the lungs is mostly performed by contraction of the diaphragm during inspiration, and muscle contraction during expiration does not play a significant role in ventilation. In contrast, during intense exercise or severe hypercapnia forced or active expiration occurs in which the abdominal “expiratory” muscles become actively involved in breathing. The mechanisms of this transition remain unknown. To study these mechanisms, we developed a computational model of the closed-loop respiratory system that describes the brainstem respiratory network controlling the pulmonary subsystem representing lung biomechanics and gas (O2 and CO2) exchange and transport. The lung subsystem provides two types of feedback to the neural subsystem: a mechanical one from pulmonary stretch receptors and a chemical one from central chemoreceptors. The neural component of the model simulates the respiratory network that includes several interacting respiratory neuron types within the Bötzinger and pre-Bötzinger complexes, as well as the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) representing the central chemoreception module targeted by chemical feedback. The RTN/pFRG compartment contains an independent neural generator that is activated at an increased CO2 level and controls the abdominal motor output. The lung volume is controlled by two pumps, a major one driven by the diaphragm and an additional one activated by abdominal muscles and involved in active expiration. The model represents the first attempt to model the transition from quiet breathing to breathing with active expiration. The model suggests that the closed-loop respiratory control system switches to active expiration via a quantal acceleration of expiratory activity, when increases in breathing rate and phrenic amplitude no longer provide sufficient ventilation. The model can be used for simulation of closed-loop control of breathing under different conditions including respiratory disorders.
Dynamics of desynchronized episodes in intermittent synchronization
(Frontiers, 2014-06) Rubchinsky, Leonid L.; Ahn, Sungwoo; Park, Choongseok; Department of Mathematical Sciences, School of Science
Intermittent synchronization is observed in a variety of different experimental settings in physics and beyond and is an established research topic in nonlinear dynamics. When coupled oscillators exhibit relatively weak, intermittent synchrony, the trajectory in the phase space spends a substantial fraction of time away from a vicinity of a synchronized state. Thus to describe and understand the observed dynamics one may consider both synchronized episodes and desynchronized episodes (the episodes when oscillators are not synchronous). This mini-review discusses recent developments in this area. We explain how one can consider variation in synchrony on the very short time-scales, provided that there is some degree of overall synchrony. We show how to implement this approach in the case of intermittent phase locking, review several recent examples of the application of these ideas to experimental data and modeling systems, and discuss when and why these methods may be useful.
Mathematical model of subthalamic nucleus neuron: Characteristic activity patterns and bifurcation analysis
(AIP, 2021-11) Park, Choongseok; Rubchinsky, Leonid L.; Ahn, Sungwoo; Mathematical Sciences, School of Science
The subthalamic nucleus (STN) has an important role in the pathophysiology of the basal ganglia in Parkinson's disease. The ability of STN cells to generate bursting rhythms under either transient or sustained hyperpolarization may underlie the excessively synchronous beta rhythms observed in Parkinson's disease. In this study, we developed a conductance-based single compartment model of an STN neuron, which is able to generate characteristic activity patterns observed in experiments including hyperpolarization-induced bursts and post-inhibitory rebound bursts. This study focused on the role of three currents in rhythm generation: T-type calcium (CaT) current, L-type calcium (CaL) current, and hyperpolarization-activated cyclic nucleotide-gated (HCN) current. To investigate the effects of these currents in rhythm generation, we performed a bifurcation analysis using slow variables in these currents. Bifurcation analysis showed that the HCN current promotes single-spike activity patterns rather than bursting in agreement with experimental results. It also showed that the CaT current is necessary for characteristic bursting activity patterns. In particular, the CaT current enables STN neurons to generate these activity patterns under hyperpolarizing stimuli. The CaL current enriches and reinforces these characteristic activity patterns. In hyperpolarization-induced bursts or post-inhibitory rebound bursts, the CaL current allows STN neurons to generate long bursting patterns. Thus, the bifurcation analysis explained the synergistic interaction of the CaT and CaL currents, which enables STN neurons to respond to hyperpolarizing stimuli in a salient way. The results of this study implicate the importance of CaT and CaL currents in the pathophysiology of the basal ganglia in Parkinson's disease.

Browsing by Author "Park, Choongseok"

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