Browsing by Author "Osccorima, Tomas"

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    Photochemical Regioselective C(sp3)-H Amination of Amides Using N-Haloimides
    (American Chemical Society, 2021) Pan, Lei; Elmasry, Joseph; Osccorima, Tomas; Cooke, Maria Victoria; Laulhé, Sébastien; Chemistry and Chemical Biology, School of Science
    A metal-free regioselective C(sp3)-H amination of amides using N-haloimides in the presence of lithium tert-butoxide and visible light is presented herein. This photoexcited approach is straightforward, and it aminates a wide variety of amides under mild conditions without the use of photocatalysts, external radical initiators, or oxidants. A halogen-bonded intermediate between the tert-butoxide base and the N-haloimide is proposed to be responsible for the increased photoreactivity. Calculations show that the formation of this electron donor-acceptor complex presents an exergonic energy profile.