Browsing by Author "Okada, Motoi"

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    Cardiac Metabolism in Sepsis
    (MDPI, 2021-12-06) Kawaguchi, Satoshi; Okada, Motoi; Anatomy, Cell Biology and Physiology, School of Medicine
    The mechanism of sepsis-induced cardiac dysfunction is believed to be different from that of myocardial ischemia. In sepsis, chemical mediators, such as endotoxins, cytokines, and nitric oxide, cause metabolic abnormalities, mitochondrial dysfunction, and downregulation of β-adrenergic receptors. These factors inhibit the production of ATP, essential for myocardial energy metabolism, resulting in cardiac dysfunction. This review focuses on the metabolic changes in sepsis, particularly in the heart. In addition to managing inflammation, interventions focusing on metabolism may be a new therapeutic strategy for cardiac dysfunction due to sepsis.