Browsing by Author "Nier, Samantha J."

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    Design and biofabrication of dermal regeneration scaffolds: role of oligomeric collagen fibril density and architecture
    (Future Science Group, 2020-02) Sohutskay, David O.; Buno, Kevin P.; Tholpady, Sunil S.; Nier, Samantha J.; Voytik-Harbin, Sherry L.; Surgery, School of Medicine
    Aim: To evaluate dermal regeneration scaffolds custom-fabricated from fibril-forming oligomeric collagen where the total content and spatial gradient of collagen fibrils was specified. Materials & methods: Microstructural and mechanical features were verified by electron microscopy and tensile testing. The ability of dermal scaffolds to induce regeneration of rat full-thickness skin wounds was determined and compared with no fill control, autograft skin and a commercial collagen dressing. Results: Increasing fibril content of oligomer scaffolds inhibited wound contraction and decreased myofibroblast marker expression. Cellular and vascular infiltration of scaffolds over the 14-day period varied with the graded density and orientation of fibrils. Conclusion: Fibril content, spatial gradient and orientation are important collagen scaffold design considerations for promoting vascularization and dermal regeneration while reducing wound contraction.