Browsing by Author "Murphy, Linda"

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    Assessment of folate receptor-β expression in human neoplastic tissues
    (Impact Journals, LLC, 2015-06-10) Shen, Jiayin; Putt, Karson S.; Visscher, Daniel W.; Murphy, Linda; Cohen, Cynthia; Singhal, Sunil; Sandusky, George; Feng, Yang; Dimitrov, Dimiter S.; Low, Philip S.; Department of Pathology & Laboratory Medicine, IU School of Medicine
    Over-expression of folate receptor alpha on cancer cells has been frequently exploited for delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited information exists on expression of the beta isoform of the folate receptor in human cancers (FR-β), we have evaluated the immunohistochemical staining pattern of FR-β in 992 tumor sections from 20 different human cancer types using a new anti-human FR-β monoclonal antibody. FR-β expression was shown to be more pronounced in cells within the stroma, primarily macrophages and macrophage-like cells than cancer cells in every cancer type studied. Moreover, FR-β expression in both cancer and stromal cells was found to be statistically more prominent in females than males. A significant positive correlation was also observed between FR-β expression on stromal cells and both the stage of the cancer and the presence of lymph node metastases. Based on these data we conclude FR-β may constitute a good target for specific delivery of therapeutic agents to activated macrophages and that accumulation of FR-β positive macrophages in the stroma could serve as a useful indicator of a tumor's metastatic potential.
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    Gender, guns, and legislating: An analysis of state legislative policy preferences
    (2008-11) Stucky, Thomas D.; Miller, Geralyn M.; Murphy, Linda
    Extant research suggests that gender affects the policy preferences of state legislators, particularly on women's issues. Fewer studies, however, have examined whether gender affects state legislators' policy preferences on other issues such as gun control. The current study uses 2000 National Political Awareness Test (NPAT) data to examine whether gender affects the preferences of state legislators regarding gun control policies. Results suggest that net of individual and constituency characteristics, female legislators are more likely to indicate support for gun control policies than their male counterparts.