Browsing by Author "Mohammed, Arooj"

Now showing 1 - 7 of 7
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    Effect of Curcuminoids in Turmeric on Developing Zebrafish Treated with Ethanol
    (Office of the Vice Chancellor for Research, 2016-04-08) Connors, Craig; Mohammed, Arooj; Muralidharan, Pooja; Sarmah, Swapnalee; Marrs, James; Marrs, Kathleen A.; Chism, Grady
    This experiment was designed with the intention of determining whether turmeric could act as a rescue agent to prevent or mitigate the extent of Fetal Alcohol Spectrum Disorder (FASD) caused by early ethanol exposure using zebrafish as a model system. A range of turmeric concentrations were made from a stock solution of turmeric dissolved in ethanol (1mg turmeric in 5mL ethanol). The active agents in turmeric are the curcuminoids: Curcumin, Desmethoxycurcumin, and Bisdemethoxycurcumin. The curcuminoids concentration was estimated using liquid chromatography. These agents were present in the turmeric stock solution at the following concentrations: Bisdemethoxycurcumin: 36.6 +/- 0.1 ug/mL, Desmethoxycurcumin: 43.4 +/- 0.1 ug/mL, and Curcumin: 124.1 +/- 0.2 ug/mL. Untreated zebrafish embryos were placed in embryo medium, ethanol treated embryos in 100mM ethanol containing embryo medium, and turmeric co-supplemented medium with differing concentrations of turmeric. Since the turmeric stock solution was dissolved in ethanol, the concentration of ethanol was kept at a constant 100mM ethanol and the amount of turmeric solution added. The concentrations of the test plates were then based on this solution and made to be 100 mM ethanol and 1.16 uM curcuminoids, 100 mM ethanol and 1.74 uM curcuminoids, and 100 mM ethanol and 2.32 uM curcuminoids. The developing embryos were treated with the turmeric solution and/or ethanol during 2-24 hours post fertilization (hpf). These embryos were imaged at 72 hpf and their body length and eye diameter were measured. The embryos supplemented with curcuminoids showed a significant rescue effect on the body length and eye diameter compared to ethanol treated embryos. This indicates that the curcuminoids acted as a rescue agent to reduce the effects that are typical of FASD in developing zebrafish.
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    Erythema nodosum treated by sulfasalazine in a pregnant patient
    (Wiley, 2020-11) Mohammed, Arooj; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
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    Extranodal NK/T-cell lymphoma primarily presenting as two adjacent slowly growing skin nodules with prominent epidermotropism and CD30 expression, a case report and review of literature
    (University of California, 2021-12-15) Mohammed, Arooj; Dave, Utpal; Rahnama-Moghadam, Sahand; Alomari, Ahmed K.; Dermatology, School of Medicine
    Extranodal NK/T-cell lymphoma (NKTCL) is a rarely occurring non-Hodgkin lymphoma with predilection for the nasal cavity. Cutaneous involvement, rarely occurring and often aggressive in behavior, may present as nodular mass-forming lesions with or without ulceration. Histologically, lesions are characterized by an atypical dermal lymphoid infiltrate with angioinvasion and associated necrosis. Fortuitously, Epstein-Barr virus (EBV) infection, implicated in the pathogenesis of this entity, serves as a useful diagnostic marker (i.e. EBER in situ hybridization). We present a 54-year-old-man who initially presented with two ulcerations on the right lower leg which progressed despite antibiotic therapy. Histologic examination demonstrated dense lymphoid infiltrates exhibiting epidermotropism, angiocentricity and angioinvasion extending into the deep dermis. Immunohistochemical staining demonstrated expression of CD2, CD3, CD8, TIA-1, perforin, and granzyme-B, consistent with a cytotoxic T-cell phenotype. Additionally, CD56 was positive, confirming the presence of a coexistent NK cell phenotype. Testing also demonstrated significant CD30 expression, and molecular analysis was positive for TCR gene rearrangement. These findings, in conjunction with EBER in situ hybridization positivity, confirmed a diagnosis of extranodal NKTCL. We aim to increase awareness of this rarely occurring lymphoma with cutaneous involvement. CD30 expression in NKTCL raises the possibility of targeted treatment with brentuximab.
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    Following the Track to an Unexpected Diagnosis: Phaeohyphomycosis
    (Elsevier, 2019) Mohammed, Arooj; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
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    The safety of rituximab for the treatment of autoimmune blistering diseases: A systematic review
    (Elsevier, 2021) Mohammed, Arooj; Hekman, Daniel; Li, Wendy; Misquith, Chelsea; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
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    Scarlatiniform Rash Caused by Mycoplasma pneumoniae
    (Cureus, 2020-06-28) Mohammed, Arooj; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
    Mycoplasma pneumoniae is a significant cause of acute respiratory disease in children and young adults. We describe a case of a 15-year-old boy who presented with an unusual scarlatiniform rash in the setting of a positive Mycoplasma pneumonia IgM but negative anti-streptolysin antibody. While mycoplasma infections with cutaneous manifestations such as scarlatiniform exanthema have been described in textbooks, there are no reports in the primary literature. We wish to highlight the recognition of alternate presentations of mycoplasma, and briefly discuss the role of molecular mimicry in its pathogenesis.
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    U-shaped neck pillow for chondrodermatitis nodularis helicis: A budget-friendly, simple alternative
    (Elsevier, 2020-02) Mohammed, Arooj; Isaacs, Michael; Rahnama, Sahand; Dermatology, School of Medicine
    Chondrodermatitis nodularis helicis (CNH) results from inflammation of the cartilage of the ear, specifically of the helix or antihelix. CNH most commonly occurs because the patient sleeps on the affected side and may also be due to sun exposure in men, who more commonly drive and are consequently vulnerable to light on the left-hand side. CNH frequently recurs unless the patient avoids repeated trauma by reducing pressure applied over the area affected. Methods suggested in the literature include attachment of ear-protective devices, sleeping with a custom CNH pillow or hemorrhoid pillow, or advising the patient to alter his/her sleeping position. However, some of our patients have found difficulty finding an effective CNH or hemorrhoid pillow.