Browsing by Author "Mishler, Dennis"

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    Early Enterococcus-associated acute postinfectious glomerulonephritis after kidney transplant.
    (Oxford University Press, 2014-08) Tandon, Teena; Mujtaba, M.; Mishler, Dennis; Phillips, Carrie; Sharfuddin, Asif; Department of Medicine, IU School of Medicine
    Postinfection as an etiology for glomerulonephritis (GN) is rarely described in post-transplant recipients and may be due to impaired immune response. It is also possible that such cases are not biopsied or not reported. There are rare case reports in the literature. We report here a rare first case of Enterococcus-related postinfectious GN in a transplant recipient seen in our center.
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    Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis
    (Wiley, 2015-09) Ali, Anum; Mishler, Dennis; Taber, Tim; Agarwal, David; Yaqub, Muhammad; Mujtaba, Muhammad; Goggins, William; Sharfuddin, Asif; Department of Medicine, IU School of Medicine
    Our aim was to study the long-term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS−ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19–136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9–2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS−ve over time. Graft survival and patient survival when compared to an age- and year of transplant-matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long-term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.