Browsing by Author "Miller, Victoria J."

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Optic Disc Edema Is an Under-Recognized Feature of Birdshot Chorioretinitis
    (Wolters Kluwer, 2024-01-25) Sabapathypillai, Sharon; Miller, Victoria J.; Shakoor, Akbar; Palestine, Alan G.; Thorne, Jennifer E.; Goldstein, Debra A.; Gaudio, Paul A.; Goldberg, Naomi; Vitale, Albert; Schlaen, Ariel; Thomas, Akshay; Merrill, Pauline T.; Raiji, Veena; Lin, Phoebe; Oliver, Armando L.; Moorthy, Ramana S.; Chandra, Gaurav; Carreno, Ester; Smith, Wendy M.; Van Stavern, Gregory; Hassman, Lynn M.; Ophthalmology, School of Medicine
    Background: Optic disc edema is a feature of many ophthalmic and neurologic conditions. It remains an underappreciated feature of birdshot chorioretinitis (BSCR), leading to delay in diagnosis and treatment. The purpose of our study was to identify clinical features that are concomitant with optic disc edema and suggest a diagnosis of BSCR. Methods: Retrospective multicenter case series of 29 patients who were referred to a neuro-ophthalmologist or uveitis specialist for evaluation of disc edema and were ultimately diagnosed with BSCR. Results: Fifty-four eyes of 30 patients, from the practices of 15 uveitis specialists, met the eligibility criteria. In addition to disc edema, concomitant features in all patients included vitritis, chorioretinal lesions, and retinal vasculitis. Visual recovery to 20/40 or better occurred in 26 of 29 patients. Visual acuity remained 20/100 or worse in 2 patients previously diagnosed with idiopathic intracranial hypertension, 1 patient previously diagnosed with optic neuritis, and 1 patient for whom treatment was delayed for years, leading to optic disc atrophy. Conclusions: Optic disc edema is a presenting feature in some cases of BSCR. A diagnosis of BSCR should be considered when disc edema occurs with vitritis, chorioretinal inflammation, and retinal vasculitis. Patients should be referred to a uveitis specialist for treatment.
  • Thumbnail Image
    Item
    Perinatal events and development of juvenile idiopathic arthritis-associated uveitis
    (Springer Nature, 2023-10-16) Chaudhary, Aysha; Nadeem, Manahil; Townsend, Jack; Miller, Victoria J.; Hajrasouliha, Amir R.; Ophthalmology, School of Medicine
    Uveitis is one of the most common manifestations of juvenile idiopathic arthritis (JIA). Currently, JIA is associated with decreased gut microbiota diversity. Studies confirm that perinatal events can cause aberrant microbial colonization. The objective of this study is to determine if JIA is associated with perinatal events with a secondary focus on these variables to the development of JIA-uveitis. 369 patients with strabismus (n = 200) or JIA (n = 196) were included in the study. Completed surveys (JIA 37; strabismus 18) collected data about birth route, pregnancy and labor complications, JIA medications, and the presence of eye disorders. Analysis indicates that there is no relationship between JIA development and the perinatal events investigated. Similarly, no significance was found between JIA-uveitis and birth route or labor complications. Pregnancy complications, namely gestational diabetes (GD), were statistically higher in the JIA group with uveitis compared to JIA without uveitis. The data from this survey study showed that JIA-uveitis was highly associated with pregnancy complications, particularly with GD. However, no statistically significant association was found between JIA and route of delivery, labor complications, or pregnancy complications. Further studies are needed to understand the ways that GD interrelates with the development of uveitis in JIA patients.