Browsing by Author "Miller, Melanie"

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    Strategic Grantmaking in Higher Education
    (Office of the Vice Chancellor for Research, 2010-04-09) Osili, Una; Miller, Melanie; Kramarek, Michal
    Resources are scarce relative to the colossal task of tackling the barriers to higher education. Delineating a grantmaking program- given the social, political, and economic dynamics in higher education- offers a substantial challenge to the nonprofit sector. The choice of strategy, implementation, and measurement are paramount considerations in effective grantmaking. Such choices include the grantmaker’s role in community and geographical contexts, allocation of grants according to location and size, engagement in partnerships and networks, and goal setting and measurement. This study investigates best practices in strategic grantmaking in the field of higher education. Through analysis of a literature review and case study interviews, this study identifies effective strategies of grantmaking organizations in addressing barriers to higher education. Such strategies include defining organizational purpose and identity, utilization of innovative techniques, adaptation to changing systems, catalyzing research, collaboration with co-funders and grantees, “big picture” goal setting, and identification and measurement of impact. The knowledge gained from this study offers grantmakers the tools needed to heighten the impact of the organizational mission under the most effective terms.
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    The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022
    (Wiley, 2024) Veitch, Dallas P.; Weiner, Michael W.; Miller, Melanie; Aisen, Paul S.; Ashford, Miriam A.; Beckett, Laurel A.; Green, Robert C.; Harvey, Danielle; Jack, Clifford R., Jr.; Jagust, William; Landau, Susan M.; Morris, John C.; Nho, Kwangsik T.; Nosheny, Rachel; Okonkwo, Ozioma; Perrin, Richard J.; Petersen, Ronald C.; Rivera Mindt, Monica; Saykin, Andrew; Shaw, Leslie M.; Toga, Arthur W.; Tosun, Duygu; Alzheimer’s Disease Neuroimaging Initiative; Radiology and Imaging Sciences, School of Medicine
    The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful studies. This review details how ADNI studies improved disease progression understanding and clinical trial efficiency. Advances in subject selection, detection of treatment effects, harmonization, and modeling improved clinical trials and plasma biomarkers like phosphorylated tau showed promise for clinical use. Biomarkers of amyloid beta, tau, neurodegeneration, inflammation, and others were prognostic with individualized prediction algorithms available online. Studies supported the amyloid cascade, emphasized the importance of neuroinflammation, and detailed widespread heterogeneity in disease, linked to genetic and vascular risk, co-pathologies, sex, and resilience. Biological subtypes were consistently observed. Generalizability of ADNI results is limited by lack of cohort diversity, an issue ADNI-4 aims to address by enrolling a diverse cohort.