Browsing by Author "Markham, Larry"

Now showing 1 - 3 of 3
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    2017 Riley Heart Center Symposium on Cardiac Development: Development and Repair of the Ventricular Wall
    (Springer Nature, 2018-08) Field, Loren J.; Shou, Weinian; Markham, Larry; Pediatrics, School of Medicine
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    Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note
    (MDPI, 2023-09-06) Panigrahy, Ashok; Schmithorst, Vanessa; Ceschin, Rafael; Lee, Vince; Beluk, Nancy; Wallace, Julia; Wheaton, Olivia; Chenevert, Thomas; Qiu, Deqiang; Lee, James N.; Nencka, Andrew; Gagoski, Borjan; Berman, Jeffrey I.; Yuan, Weihong; Macgowan, Christopher; Coatsworth, James; Fleysher, Lazar; Cannistraci, Christopher; Sleeper, Lynn A.; Hoskoppal, Arvind; Silversides, Candice; Radhakrishnan, Rupa; Markham, Larry; Rhodes, John F.; Dugan, Lauryn M.; Brown, Nicole; Ermis, Peter; Fuller, Stephanie; Cotts, Timothy Brett; Rodriguez, Fred Henry; Lindsay, Ian; Beers, Sue; Aizenstein, Howard; Bellinger, David C.; Newburger, Jane W.; Glass Umfleet, Laura; Cohen, Scott; Zaidi, Ali; Gurvitz, Michelle; Pediatric Heart Network MINDS Neuroimaging Ancillary Study Investigators; Radiology and Imaging Sciences, School of Medicine
    Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e.g., level of education and lifestyle/social habits). This technical note describes an ancillary study to the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study (MINDS) in Adult Congenital Heart Disease (ACHD)”. Leveraging clinical, neuropsychological, and biospecimen data from the parent study, our study will provide structural–physiological correlates of neurocognitive outcomes, representing the first multi-center neuroimaging initiative to be performed in ACHD patients. Limitations of the study include recruitment challenges inherent to an ancillary study, implantable cardiac devices, and harmonization of neuroimaging biomarkers. Results from this research will help shape the care of ACHD patients and further our understanding of the interplay between brain injury and cognitive reserve.
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    The american pediatric society and society for pediatric research joint statement against racism and social injustice
    (Springer Nature, 2022) Abman, Steven H.; Armstrong, Sarah; Baker, Susan; Bogue, Clifford W.; Carlo, Waldemar; Chalak, Lina; Daniels, Stephen R.; Davis, Stephanie; Debaun, Michael R.; Fike, Candice; Frazer, Lauren; Gibson, Keisha; Gill, Michelle; Glass, Hannah; Gordon, Catherine M.; Goyal, Monika; Hirschhorn, Joel; Holtz, Lori; Hunstad, David A.; Leonard, Mary B.; Maitre, Nathalie; Markham, Larry; McAllister-Lucas, Linda; Orange, Jordan; Shah, Prachi; Simon, Tamara; Steinhorn, Robin H.; Tarini, Beth; Walker-Harding, Leslie R.; Pediatrics, School of Medicine