Browsing by Author "Machogu, Evans M."

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Apical Lung Herniation Associated with Continuous Positive Airway Pressure in a 4-Year-Old Girl
    (American Academy of Sleep Medicine, 2016-11-15) Lehmann, Christopher J.; Daftary, Ameet S.; Machogu, Evans M.; Medicine, School of Medicine
    We report a case of apical lung herniation through the superior thoracic aperture of an obese child using nocturnal CPAP. Lung herniation has been described in association with congenital thoracic abnormalities and elevated intra-thoracic pressure, such as trauma. This patient was hospitalized with community acquired pneumonia and required nocturnal CPAP for treatment of concurrent obstructive sleep apnea. Her lung hernia was discovered incidentally on routine follow-up chest radiography and resolved with cessation of CPAP treatment. Lung herniation in association with the use of continuous positive airway pressure (CPAP) has not been previously described.
  • Thumbnail Image
    Item
    Lung clearance index in children with sickle cell disease
    (Wiley, 2021-05) Machogu, Evans M.; Khurana, Monica; Kaericher, Jennifer; Clem, Charles C.; Slaven, James E.; Hatch, Joseph E.; Davis, Stephanie D.; Peterson-Carmichael, Stacey; Pediatrics, School of Medicine
    Introduction The lung clearance index (LCI) derived from the multiple breath washout test (MBW), is both feasible and sensitive to early lung disease detection in young children with cystic fibrosis and asthma. The utility of LCI has not been studied in children with sickle cell disease (SCD). We hypothesized that children with SCD, with or without asthma or airway hyperreactivity (AHR), would have an elevated LCI compared to healthy controls. Methods Children with SCD from a single center between the ages of 6 and 18 years were studied at baseline health and completed MBW, spirometry, plethysmography and blood was drawn for serum markers. Results were compared to healthy controls of similar race, age, and gender. Results Healthy controls (n = 35) had a significantly higher daytime oxygen saturation level, weight and body mass index but not height compared to participants with SCD (n = 34). Total lung capacity (TLC) z-scores were significantly higher in the healthy controls compared to those with SCD (0.87 [1.13] vs. 0.02 [1.27]; p = .005) while differences in forced expiratory volume in 1 s z-scores approached significance (0.26 [0.97] vs. −0.22 [1.09]; p = .055). There was no significant difference in LCI between the healthy controls compared to participants with SCD (7.29 [0.72] vs. 7.40 [0.69]; p = .514). Conclusion LCI did not differentiate SCD from healthy controls in children between the ages of 6 and 18 years at baseline health. TLC may be an important pulmonary function measure to follow longitudinally in the pediatric SCD population.
  • Thumbnail Image
    Item
    Racial disparities in primary ciliary dyskinesia: Defining the problem and potential solutions
    (Wiley, 2023) Carr, Katherine A.; O’Connor, Michael G.; Shapiro, Adam J.; Machogu, Evans M.; Medicine, School of Medicine