Browsing by Author "Maatman, Benjamin"

Now showing 1 - 4 of 4
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    Fibrin clot strength measured by thrombelastography and outcomes after percutaneous coronary intervention
    (Thieme, 2017-01-26) Kreutz, Rolf P.; Schmeisser, Glen; Maatman, Benjamin; Schaffter, Andrea; Sinha, Anjan; von der Lohe, Elisabeth; Breall, Jeffrey A.; Medicine, School of Medicine
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    Mitral Annular Plane Systolic Excursion: An Early Marker of Mortality in Severe COVID-19 Infection
    (Elsevier, 2020-08-18) Jarori, Upasana; Maatman, Thomas K.; Maatman, Benjamin; Mastouri, Ronald; Sawada, Stephen G.; Khemka, Abhishek; Medicine, School of Medicine
    Respiratory failure is a major cause of mortality among hospitalized patients with COVID-19. Previous studies have shown that right ventricular (RV) dilation and reduced RV longitudinal strain are markers of poor outcome in this disease. COVID-19 can cause direct myocardial injury resulting in left ventricular (LV) systolic dysfunction and heart failure suggesting that assessment of LV function might also have prognostic value. Reduction of longitudinal systolic function assessed by mitral annular plane systolic excursion (MAPSE) is an early indicator of myocardial disease in various cardiac disorders. In this retrospective study, we investigated the prognostic value of MAPSE in patients admitted with respiratory failure related to COVID-19 infection.
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    Prediction of Ischemic Events after Percutaneous Coronary Intervention: Thrombelastography Profiles and Factor XIIIa Activity
    (Thieme Medical Publishers, 2018-04) Kreutz, Rolf P.; Schmeisser, Glen; Schaffter, Andrea; Kanuri, Sri; Owens, Janelle; Maatman, Benjamin; Sinha, Anjan; Lohe, Elisabeth von der; Breall, Jeffrey A.; Medicine, School of Medicine
    Background: High plasma fibrin clot strength (MA) measured by thrombelastography (TEG) is associated with increased risk of cardiac events after percutaneous coronary interventions (PCIs). Factor XIIIa (FXIIIa) cross-links soluble fibrin, shortens clot formation time (TEG-K), and increases final clot strength (MA). Methods: We analyzed platelet-poor plasma from patients with previous PCI. Kaolin-activated TEG (R, K, MA) in citrate platelet-poor plasma and FXIIIa were measured (n = 257). Combined primary endpoint was defined as recurrent myocardial infarction (MI) or cardiovascular death (CVD). Relationship of FXIIIa and TEG measurements on cardiac risk was explored. Results: FXIIIa correlated with TEG-MA (p = 0.002) and inversely with TEG-K (p < 0.001). High MA (≥35.35 mm; p = 0.001), low K (<1.15 min; p = 0.038), and elevated FXIIIa (≥83.51%; p = 0.011) were associated with increased risk of CVD or MI. Inclusion of FXIIIa activity and low TEG-K in risk scores did not improve risk prediction as compared with high TEG-MA alone. Conclusion: FXIIIa is associated with higher plasma TEG-MA and low TEG-K. High FXIIIa activity is associated with a modest increase in cardiovascular risk after PCI, but is less sensitive and specific than TEG-MA. Addition of FXIIIa does not provide additional risk stratification beyond risk associated with high fibrin clot strength phenotype measured by TEG.
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    The role of exercise in atrial fibrillation prevention and promotion: Finding optimal ranges for health
    (Elsevier, 2017) Elliott, Adrian D.; Maatman, Benjamin; Emery, Michael S.; Sanders, Prashanthan; Department of Medicine, School of Medicine
    The cardiovascular benefits of regular exercise have been well described, including a significant reduction in cardiovascular morbidity and mortality for those meeting recommended guidelines. Yet the impact of physical activity on the incidence of atrial fibrillation (AF) has been less clear. This review seeks to define the optimal dose and duration for the prevention and treatment of AF. In doing so, we review the evidence that supports a decline in AF risk for those who achieve a weekly physical activity dose slightly above the current recommended guidelines. Furthermore, we identify the reduced AF incidence in those individuals who attain a cardiorespiratory fitness of 8 METs (metabolic equivalents of task) or more during maximal exercise testing. Finally, we review the evidence that shows an excess of AF among regular participants of endurance exercise.