Browsing by Author "Liu, Lichuan"

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    Multimodal Data Analytics for Assessing Collaborative Interactions
    (International Society of the Learning Sciences (ISLS), 2020-06) Kim, Yanghee; D'Angelo, Cynthia; Cafaro, Francesco; Ochoa, Xavier; Espino, Danielle; Kline, Aaron; Hamilton, Eric; Lee, Seung; Butail, Sachit; Liu, Lichuan; Trajkova, Milka; Tscholl, Michael; Hwang, Jaejin; Lee, Sungchul; Kwon, Kyungbin; Human-Centered Computing, School of Informatics and Computing
    This symposium will discuss the current status of the research and development of multimodal data analytics (MDA) for the observation of collaboration. Five research groups will present their current work on MDA, each with a unique focus on different data sources and different approaches to the analysis and synthesis of multimodal data sets. A few themes emerge from these studies: i) the studies seek to examine collaborative behaviors as a process in ordinary settings, both formal and informal; ii) with MDA being in its early stage, manual and computational approaches are taken complementarily, also using human annotation as the ground truth for the computational approach; and iii) several different discipline-specific research and development lines contribute integrally to generating authentic measures of collaborative interactions in situ, making this line of research transdisciplinary.
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    Photoredox/Pyridine N-Oxide Catalyzed Carbohydroxylation and Aminohydroxylation of α-Olefins
    (ACS, 2025) Ascenzi Pettenuzzo, Cristina; Pradhan, Deepak Ranjan; Singh, Jujhar; Liu, Lichuan; Cuffel, Gabe; Vetticatt, Mathew J.; Deng, Yongming; Chemistry and Chemical Biology, School of Science
    Regioselective carbohydroxylation and aminohydroxylation of α-olefins were developed by a photoredox catalyst and pyridine N-oxide. This approach offers the catalytic and direct conversion of unactivated alkenes to a series of primary alcohols, including those bearing β-quaternary carbon centers and β-amino alcohols. The regioselective difunctionalization is enabled by the radical addition of α-olefin from the pyridine N-oxy radical, which is generated from readily available pyridine N-oxide via photoredox catalyzed single-electron oxidation. A combination of experimental and computational mechanistic studies was employed to lend support for the proposed reaction mechanism that proceeds via interwoven radical steps and polar substitution. The implications of this method for regioselective difunctionalization of α-olefins were further demonstrated by the examples of carboetherification, carboesterification, and lactone formation.