Browsing by Author "Liu, Jiayi"

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    Industry convergence in rural tourism development: a China-featured term or a new initiative?
    (Taylor & Francis, 2018) Shen, Weili; Liu-Lastres, Bingjie; Pennington-Gray, Lori; Hu, Xiaohai; Liu, Jiayi; Tourism, Conventions, and Event Management, School of Health and Human Sciences
    Industry convergence is a popular term that has been widely referenced in the context of rural tourism development in China. All levels of government (local, regional, national) in China have repeatedly addressed the significance of industry convergence in their tourism plans and related policies. Despite its popularity, limited studies at present have explored this concept in-depth. Using Huai’an as a case, this study applied a path analysis and reported the industry convergence process in a destination. The findings of this study can provide both theoretical and practical implications that are useful for tourism planners and policy makers.
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    Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model
    (American Association for the Advancement of Science, 2024) Li, Xindi; Liu, Jiayi; Boreland, Andrew J.; Kapadia, Sneha; Zhang, Siwei; Stillitano, Alessandro C.; Abbo, Yara; Clark, Lorraine; Lai, Dongbing; Liu, Yunlong; Barr, Peter B.; Meyers, Jacquelyn L.; Kamarajan, Chella; Kuang, Weipeng; Agrawal, Arpana; Slesinger, Paul A.; Dick, Danielle; Salvatore, Jessica; Tischfield, Jay; Duan, Jubao; Edenberg, Howard J.; Kreimer, Anat; Hart, Ronald P.; Pang, Zhiping P.; Biochemistry and Molecular Biology, School of Medicine
    Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet their molecular implications remain underexplored. Neuroimmune interactions, particularly in microglia, are recognized as notable contributors to AUD pathophysiology. We investigated the interplay between AUD PRS and ethanol in human microglia derived from iPSCs from individuals with AUD high-PRS (diagnosed with AUD) or low-PRS (unaffected). Ethanol exposure induced elevated CD68 expression and morphological changes in microglia, with differential responses between high-PRS and low-PRS microglial cells. Transcriptomic analysis revealed expression differences in MHCII complex and phagocytosis-related genes following ethanol exposure; high-PRS microglial cells displayed enhanced phagocytosis and increased CLEC7A expression, unlike low-PRS microglial cells. Synapse numbers in cocultures of induced neurons with microglia after alcohol exposure were lower in high-RPS cocultures, suggesting possible excess synapse pruning. This study provides insights into the intricate relationship between AUD PRS, ethanol, and microglial function, potentially influencing neuronal functions in developing AUD.