Browsing by Author "Lee, Chihyi"

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    Molecular diagnosis and therapy for Plasmodium ovale infection of a returned traveler from East Africa
    (Elsevier, 2021-05-06) Tseng, Yu-Chuan; Chang, Yu-Chang; Lee, Chihyi; Hsu, Shih-Fen; Chang, Pai-Chuan; Hsu, Jen-Jen; Lin, Peter Bor-Chian; Lu, Min-Chi; Tien, Ni; Hsiao, Chiung-Tzu; Medicine, School of Medicine
    Malaria is an infectious disease caused by Plasmodium parasites that are mainly transmitted through the bites of infected female Anopheles mosquitoes. The average annual number of malaria cases was less than ten in Taiwan in the last five years. Most of the cases were caused by Plasmodium vivax and Plasmodium falciparum, and were primarily diagnosed in travelers who returned from Southeast Asia and Africa. Here, we report the first case of Plasmodium ovale infection within five years that was confirmed by peripheral blood smear examination and molecular identification in a 25-year-old Asian female patient who returned from Uganda.
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    The Role of Urocortins in Intracerebral Hemorrhage
    (MDPI, 2020-01) Choy, KerWoon; Tsai, Andy Po-Yi; Lin, Peter Bor-Chian; Wu, Meng-Yu; Lee, Chihyi; Alias, Aspalilah; Pang, Cheng-Yoong; Liew, Hock-Kean; Neurology, School of Medicine
    Intracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite extensive clinical trials, no medical or surgical therapy has shown to be effective in managing ICH, resulting in a poor prognosis for the patients. Urocortin (UCN) is a 40-amino-acid endogenous neuropeptide that belongs to the corticotropin-releasing hormone (CRH) family. The effect of UCN is activated by binding to two G-protein coupled receptors, CRH-R1 and CRH-R2, which are expressed in brain neurons and glial cells in various brain regions. Current research has shown that UCN exerts neuroprotective effects in ICH models via anti-inflammatory effects, which generally reduced brain edema and reduced blood-brain barrier disruption. These effects gradually help in the improvement of the neurological outcome, and thus, UCN may be a potential therapeutic target in the treatment of ICH. This review summarizes the data published to date on the role of UCN in ICH and the possible protective mechanisms underlined.