Browsing by Author "Krammer, Florian"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Asymptomatic Seroconversion of Immunoglobulins to SARS-CoV-2 in a Pediatric Dialysis Unit
    (American Medical Association, 2020-05-14) Hains, David S.; Schwaderer, Andrew L.; Carroll, Aaron E.; Starr, Michelle C.; Wilson, Amy C.; Amanat, Fatima; Krammer, Florian; Pediatrics, School of Medicine
    Dialysis units are at especially high risk of infectious disease transmission, and concern exists about spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Dialysis units in Wuhan, China, have reported high coronavirus disease 2019 (COVID-19) prevalence, due in part to unique exposure challenges that limit social distancing efforts, including open bay formats and rotating/multiple nursing assignments. This study describes SARS-CoV-2 seroconversion in patients and health care workers in a pediatric dialysis unit.
  • Thumbnail Image
    Item
    Determinants of health as predictors for differential antibody responses following SARS-CoV-2 primary and booster vaccination in an at-risk, longitudinal cohort
    (Public Library of Science, 2024-04-02) Echeverri Tribin, Felipe; Williams, Erin; Testamarck, Valeska; Carreño, Juan Manuel; Bielak, Dominika; Yellin, Temima; Krammer, Florian; Hoffer, Michael; Pallikkuth, Suresh; Pahwa, Savita; Medicine, School of Medicine
    Post vaccine immunity following COVID-19 mRNA vaccination may be driven by extrinsic, or controllable and intrinsic, or inherent health factors. Thus, we investigated the effects of extrinsic and intrinsic on the peak antibody response following COVID-19 primary vaccination and on the trajectory of peak antibody magnitude and durability over time. Participants in a longitudinal cohort attended visits every 3 months for up to 2 years following enrollment. At baseline, participants provided information on their demographics, recreational behaviors, and comorbid health conditions which guided our model selection process. Blood samples were collected for serum processing and spike antibody testing at each visit. Cross-sectional and longitudinal models (linear-mixed effects models) were generated to assess the relationship between selected intrinsic and extrinsic health factors on peak antibody following vaccination and to determine the influence of these predictors on antibody over time. Following cross-sectional analysis, we observed higher peak antibody titers after primary vaccination in females, those who reported recreational drug use, younger age, and prior COVID-19 history. Following booster vaccination, females and Hispanics had higher peak titers after the 3rd and 4th doses, respectively. Longitudinal models demonstrated that Moderna mRNA-1273 recipients, females, and those previously vaccinated had increased peak titers over time. Moreover, drug users and half-dose Moderna mRNA-1273 recipients had higher peak antibody titers over time following the first booster, while no predictive factors significantly affected post-second booster antibody responses. Overall, both intrinsic and extrinsic health factors play a significant role in shaping humoral immunogenicity after initial vaccination and the first booster. The absence of predictive factors for second booster immunogenicity suggests a more robust and consistent immune response after the second booster vaccine administration.
  • Thumbnail Image
    Item
    Longitudinal SARS-CoV-2 seroconversion and functional heterogeneity in a pediatric dialysis unit
    (Elsevier, 2021-02) Canas, Jorge J.; Starr, Michelle C.; Arregui, Samuel; Wilson, Amy C.; Carroll, Aaron E.; Saxena, Vijay; Amanat, Fatima; Krammer, Florian; Fill, Jeffrey; Schade, Andrew; Chambers, Antonio; Schneider, Jack; Schwaderer, Andrew L.; Hains, David S.; Pediatrics, School of Medicine