Browsing by Author "Klein, Andrew"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
    (Elsevier, 2024-12-27) Ranade, Mona; Foster, Malcolm T., III; Brady, Paul S.; Sokol, Seth I.; Butty, Sabah; Klein, Andrew; Maholic, Robert; Safar, Ammar; Patel, Taral; Zlotnick, David; Gans, Daniel; Pollak, Jeffrey; Ferrera, Dean; Stegman, Brian; Basra, Sukhdeep; Moriarty, John; Keeling, Brent; APEX-AV Investigators; Radiology and Imaging Sciences, School of Medicine
    Background: There is a need for additional data to assess procedural efficacy and risks associated with mechanical thrombectomy for treating pulmonary embolism (PE) due to its increased utilization and diversity of patient populations presenting with PE. This study evaluated the safety and efficacy of percutaneous mechanical aspiration thrombectomy with the AlphaVac F1885 System (AngioDynamics) in patients with acute intermediate-risk PE. Methods: Patients with acute intermediate-risk PE and a right ventricular (RV)/left ventricular (LV) diameter ratio of ≥0.9 were eligible for enrollment in this prospective, multicenter, single-arm study. The primary effectiveness end point was reduction in the RV/LV ratio at 48 hours. The primary safety end point was the rate of major adverse events (MAEs) defined as subjects who experienced major bleeding, device-related deaths, clinical deterioration, or pulmonary vascular or cardiac injury within 48 hours postprocedurally. Results: In total, 122 subjects were enrolled at 25 sites. Mean procedure time was 37.2 ± 17.7 minutes. There were statistically significant reductions in mean 48-hour postprocedural RV/LV diameter ratio (-0.45 ± 0.27; P < .001). Postprocedural mean pulmonary arterial pressure also significantly declined from 27.8 ± 7.8 mm Hg before the procedure to 21.8 ± 7.2 mm Hg (P < .001). There was a 35.5% mean reduction in clot burden as measured by the modified Miller index score. Five (4.1%) subjects developed 7 MAEs during the postprocedural 48-hour assessment period, the majority of which were access site bleeding. Conclusions: Percutaneous mechanical aspiration thrombectomy with the AlphaVac system provided a safe and effective treatment for acute intermediate-risk PE with a significant reduction in RV/LV ratio and clot burden with a low rate of adverse events.
  • Thumbnail Image
    Item
    Upward! Higher: How a Law Faculty Stays Ahead of the Curve
    (2018) Adams, Cynthia; Baker, Cynthia; Boyne, Shawn; Huffman, Max; Klein, Andrew; Ryznar, Margaret; Shope, Mark; Sullivan, Frank
    Full-time and part-time faculty of the IUMcKinney School ofLaw convened together with campus and university partners from the IUPUI Center for Teaching and Learning and Indiana University e-Learning Design and Services for the second annual "Upward!" teaching symposium at the beginning ofFall Semester 2017. The two-day gathering involved panel discussions on topics including online teaching, online course design, teaching externships, designing lessons for the law school's active learning classrooms, teaching international students, and teaching with an eye to the bar exam. Participants enjoyed afield trip to IUPUI campus offices supporting the university's teaching mission, including the Center for Teaching and Learning and the recording studio. Panelists contributed to this joint publication, which includes sole- or joint- authored submissions by Professors Adams, Baker, Boyne, Huffinan, Ryznar, Shope, and Sullivan; an introduction by Dean Klein and Professor Huffman; and reactions to the primary papers. These submissions reflect a variety ofscholarly methods, drawing from empirical study, anecdotal observation, and theoretical analysis. The written submissions from Upward! combine to relate a story of law school curricular, student body, and course design that responds to the changing needs and realities of the profession and student demand. The Introduction by Dean Klein and Professor Huffinan explains that design is a combination of top- down direction and bottom-up faculty-led innovation. As law schools continue to cope with uncertainties, including a changing regulatory environment, and resource constraints, the McKinney model offers an approach to purposeful change.