Browsing by Author "Khizroev, S."

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    Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles
    (Elsevier, 2022) Zhang, E.; Abdel-Mottaleb, M.; Liang, P.; Navarrete, B.; Akin Yildirim, Y.; Alberteris Campos, M.; Smith, I. T.; Wang, P.; Yildirim, B.; Yang, L.; Chen, S.; Smith, I.; Lur, G.; Nguyen, T.; Jin, X.; Noga, B. R.; Ganzer, P.; Khizroev, S.; Anesthesia, School of Medicine
    The in vitro study demonstrates wirelessly controlled modulation of neural activity using magnetoelectric nanoparticles (MENPs), synchronized to magnetic field application with a sub-25-msec temporal response. Herein, MENPs are sub-30-nm CoFe2O4@BaTiO3 core-shell nanostructures. MENPs were added to E18 rat hippocampal cell cultures (0.5 μg of MENPs per 100,000 neurons) tagged with fluorescent Ca2+ sensitive indicator cal520. MENPs were shown to wirelessly induce calcium transients which were synchronized with application of 1200-Oe bipolar 25-msec magnetic pulses at a rate of 20 pulses/sec. The observed calcium transients were similar, in shape and magnitude, to those generated through the control electric field stimulation with a 50-μA current, and they were inhibited by the sodium channel blocker tetrodotoxin. The observed MENP-based magnetic excitation of neural activity is in agreement with the non-linear M - H hysteresis loop of the MENPs, wherein the MENPs' coercivity value sets the threshold for the externally applied magnetic field.