Browsing by Author "Katz, Amy"

Now showing 1 - 4 of 4
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    Menstrual Dysfunction and Treatment Among Adolescents With Congenital Heart Disease
    (Elsevier, 2020) Leroy-Melamed, Maayan; Katz, Amy; Shew, Marcia L.; Pediatrics, School of Medicine
    Study Objective This study describes menstrual dysfunction and treatment among adolescent and young adult (AYA) females with congenital heart disease (CHD). Design Data collected from a 1-time survey completed by AYA females (and mothers if AYA unable). Setting Participants were recruited from pediatric cardiology clinics. Participants Female AYA with CHD, aged 14-21 years (N = 114). Interventions None. Main Outcome Measures The questionnaire assessed sexual and reproductive health (SRH) concerns, behaviors, and management. Outcome measures were self-reported menstrual complaints, use of over-the-counter (OTC) pain relief medications for dysmenorrhea, reported visits with a clinician for a menstrual problem, and reported use of hormones for menstrual problems or birth control. Results Mean age was 17.0 years (SD = 2.2). The majority of participants (83%) reported 1 or more menstrual complaints (67.5% cramping, 42.1% irregular menses, 46.5% heavy periods), and 88% reported any history of taking OTC medications for pain relief. Increased menstrual complaints were not associated with level of cardiac complexity, reported transplantation, or reported use of hormonal contraception. However, 32% of participants reported use of hormonal contraception for menstrual dysfunction. Combined oral contraceptive pills (COCs) were the most common; 2 of these women carried contraindications to estrogen. Conclusions A large majority of AYA females with CHD reported menstrual dysfunction. Use of OTC medication for menstrual pain and inappropriate use of estrogen creates concerns that menstrual disorders may be unaddressed or addressed inappropriately. Thus, gynecological needs of adolescents with CHD may need to be specifically targeted by providers who feel comfortable with this population and their complex needs.
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    Patient-Reported Outcomes in Autosomal Dominant Osteopetrosis: Findings From the Osteopetrosis Registry Study
    (Oxford University Press, 2025) Polgreen, Lynda E.; Villa-Lopez, Eva; Chen, Liz; Liu, Ziyue; Katz, Amy; Parks-Schenck, Corinne; Hart, Marian; Imel, Erik A.; Econs, Michael J.; Biostatistics and Health Data Science, Richard M. Fairbanks School of Public Health
    Context: Autosomal dominant osteopetrosis (ADO) is a rare sclerotic bone disease characterized by impaired osteoclast activity, resulting in high bone mineral density and skeletal fragility. The full phenotype and disease burden on patients' daily lives has not been systematically measured. Objective: We developed an online registry to ascertain population-based data on the spectrum and rate of progression of disease and to identify relevant patient-centered outcomes that could be used to measure treatment effects and guide the design of future clinical trials. Methods: Cross-sectional data from participants with osteopetrosis were collected using an online REDCap-based database. Thirty-four participants with a confirmed diagnosis of ADO, aged 4-84 years were included. Participants aged 18 years and older completed the PROMIS 57, participants aged 8-17 years completed the PROMIS Pediatric 49, and parents of participants aged <18 years completed the PROMIS Parent Proxy 49. Results: Based on the PROMIS 57, relative to the general population, adults with ADO reported low physical function and low ability to participate in social roles and activities, and high levels of anxiety, fatigue, sleep problems, and pain interference. Daily pain medications were reported by 24% of the adult population. In contrast, neither pediatric participants nor their parent proxy reported a negative impact on health-related quality of life. Conclusion: Data from this registry demonstrate the broad spectrum of ADO disease severity and high impact on health-related quality of life in adults with ADO.
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    Risk and Protective Factors for Bullying Victimization and Perpetration among System-Involved Youth
    (American Public Health Association, 2019) Katz, Amy; Hunt, Abby; Zaban, Leigh; Hensel, Devon; Ott, Mary A.
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    Youth Connectedness Mitigates the Impact of Adverse Childhood Experiences (ACEs) on Adolescent Substance Use in a Rural Midwest County
    (APHA's 2019 Annual Meeting and Expo (Nov. 2-Nov. 6), 2019) Cope-Barnes, Doug; Hensel, Devon; Katz, Amy; Zaban, Leigh; Hunt, Abby; Ott, Mary A.
    Background: Adverse Childhood Experiences (ACEs) increase the risk of adolescent substance abuse. Positive youth connections may mitigate these negative effects. We test whether and how home and school connectedness influences adolescent substance use. Methods: Youth (N=1651 6 th to 8 th graders, N=565, 10 th graders) from a rural, Midwestern low to middle income school district completed a baseline questionnaire prior to a health education program. The outcome, substance use, was a mean index of eight reported substance use behaviors (tobacco, electronic vapor, alcohol, any marijuana [organic or synthetic], prescription pills, inhalants, IV injection; all 6 categories: never to 40+ times). Structural equation modeling (SEM) was used to evaluate both the direct and indirect relationships between ACEs (middle school (MS), α =.700; high school (HS), α=.740), school- (MS α =.805; HS α=.833) and parent- connectedness (MS α =.923; HS α=.942) and substance use (Stata, 15.1). Results: Higher ACEs was directly associated with lower school connectedness (MS: B=-0.29, p<.000; HS: B=- 0.27, p<.000) and lower parent connectedness (MS: B=-0.16, p<.000; HS: B=-0.23, p<.000). Higher school connectedness (MS: B=-0.19; p<.000; HS: B=-0.14, p<.000), higher parent connectedness (MS: B=-0.09; p<.000; HS: B=-0.209, p<.000) and lower ACEs (MS: B=0.27; p<.000; HS: B=-.17, p<000) all directly associated with lower substance use. The impact of ACEs on substance use was mitigated indirectly through higher school connectedness (MS: B=0.01, p<.000; HS: B=0.03, p<.000) and parent connectedness (MS: B=0.03, p<.000; HS: B=-=0.01, p<.000). Conclusion: Prevention programs should be trauma-informed and incorporate parent-youth and teacher-student components.