Browsing by Author "Kaffenberger, Benjamin H."

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    Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment
    (MDPI, 2023-10-10) Diaz, Michael J.; Natarelli, Nicole; Wei, Aria; Rechdan, Michaela; Botto, Elizabeth; Tran, Jasmine T.; Forouzandeh, Mahtab; Plaza, Jose A.; Kaffenberger, Benjamin H.; Medicine, School of Medicine
    Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder characterized by inflammatory arthritis and periarticular structural damage. Available evidence suggests that RA results from complex interactions between genetic susceptibility (e.g., HLA-DRB1), environmental factors (e.g., smoking), and immune dysregulation. Alongside joint-related symptoms, individuals with RA may also experience a wide array of skin issues, including the development of nodules, neutrophilic dermatoses, vasculitis, and vasculopathy. Treatment strategies for these manifestations vary but routinely involve corticosteroids, disease-modifying anti-rheumatic drugs, and biologics, with individualized approaches guided by disease severity. In this review, we provide comprehensive insights into the skin-related issues associated with RA, outlining their clinical characteristics and histopathological findings. Our aim is to facilitate early diagnosis and personalized treatment to improve the quality of life of affected individuals.
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    Society of Dermatology Hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults
    (Elsevier, 2020-06) Seminario-Vidal, Lucia; Kroshinsky, Daniela; Malachowski, Stephen J.; Sun, James; Markova, Alina; Beachkofsky, Thomas M.; Kaffenberger, Benjamin H.; Ergen, Elizabeth N.; Mauskar, Melissa; Bridges, Alina; Calhoun, Cody; Cardones, Adela R.; Chen, Steven T.; Chodosh, James; Cotliar, Jonathan; Davis, Mark D. P.; DeNiro, Katherine L.; Dominguez, Arturo R.; Eljure-Téllez, Juliana; Femia, Alisa; Fox, Lindy P.; Guda, Anisha; Mitchell, Caroline; Mostaghimi, Arash; Ortega-Loayza, Alex G.; Owen, Cindy; Pasieka, Helena; Rahnama-Moghadam, Sahand; Saeed, Hajirah N.; Saunderson, Rebecca B.; Shanbhag, Swapna; Sharon, Victoria R.; Strowd, Lindsay; Venkatesh, Samantha; Wanat, Karolyn A.; Wetter, David A.; Worswick, Scott; Micheletti, Robert G.; Dermatology, School of Medicine
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions with high morbidity and mortality. Supportive care management of SJS/TEN is highly variable. A systematic review of the literature was performed by dermatologists, ophthalmologists, intensivists, and gynecologists with expertise in SJS/TEN to generate statements for supportive care guideline development. Members of the Society of Dermatology Hospitalists with expertise in SJS/TEN were invited to participate in a modified, online Delphi-consensus. Participants were administered 9-point Likert scale questionnaires regarding 135 statements. The RAND/UCLA Appropriateness Method was used to evaluate and select proposed statements for guideline inclusion; statements with median ratings of 6.5 to 9 and a disagreement index of ≤1 were included in the guideline. For the final round, the guidelines were appraised by all of the participants. Included are an evidence-based discussion and recommendations for hospital setting and care team, wound care, ocular care, oral care, urogenital care, pain management, infection surveillance, fluid and electrolyte management, nutrition and stress ulcer prophylaxis, airway management, and anticoagulation in adult patients with SJS/TEN.