Browsing by Author "Irizarry, Michael C."

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    Topographic staging of tau positron emission tomography images
    (Elsevier, 2018-02-14) Schwarz, Adam J.; Shcherbinin, Sergey; Slieker, Lawrence J.; Risacher, Shannon L.; Charil, Arnaud; Irizarry, Michael C.; Fleisher, Adam S.; Southekal, Sudeepti; Joshi, Abhinay D.; Devous, Michael D., Sr.; Miller, Bradley B.; Saykin, Andrew J.; Alzheimer's Disease Neuroimaging Initiative; Radiology and Imaging Sciences, School of Medicine
    Introduction: It has been proposed that the signal distribution on tau positron emission tomography (PET) images could be used to define pathologic stages similar to those seen in neuropathology. Methods: Three topographic staging schemes for tau PET, two sampling the temporal and occipital subregions only and one sampling cortical gray matter across the major brain lobes, were evaluated on flortaucipir F 18 PET images in a test-retest scenario and from Alzheimer's Disease Neuroimaging Initiative 2. Results: All three schemes estimated stages that were significantly associated with amyloid status and when dichotomized to tau positive or negative were 90% to 94% concordant in the populations identified. However, the schemes with fewer regions and simpler decision rules yielded more robust performance in terms of fewer unclassified scans and increased test-retest reproducibility of assigned stage. Discussion: Tau PET staging schemes could be useful tools to concisely index the regional involvement of tau pathology in living subjects. Simpler schemes may be more robust.