Browsing by Author "Holland, Mark"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    IUPUI Imaging Research Initiative
    (Office of the Vice Chancellor for Research, 2013-04-05) Holland, Mark; Barnett, William; Burr, David B.; Day, Richard; Du, Eliza Y.; Gattone, Vincent, III; Fletcher, James; Johnson, Daniel P.; Long, Eric; Molitoris, Bruce A.; Palakal, Mathew; Salama, Paul; Sturek, Michael; Hutchins, Gary D.
    Imaging has become an essential research tool in a majority of scientific disciplines. The IUPUI Imaging Research Initiative (IRI) has been established to bring together researcher investigators who develop novel imaging technologies with those who utilize imaging tools to advance their research with the primary objective of building a large scale imaging research infrastructure at IUPUI. An Imaging Research Council has been created to establish priorities for the IRI and help guide the development of an IUPUI research imaging infrastructure and sustainable research funding base. The specific goals of the council include: • To encourage and coordinate collaboration among IUPUI researchers from different disciplines • To provide advice and guidance in the realization of highly competitive large grant proposals that will support and grow the IUPUI imaging efforts into major nationally and internationally recognized programs • To develop a strategic plan that will enable IUPUI to become nationally and internationally known as the place for imaging research and its applications • To determine strategic areas of strength and growth • To determine available and needed resources • To determine strategic external partnerships
  • Thumbnail Image
    Item
    IUPUI Imaging Research Initiative
    (Office of the Vice Chancellor for Research, 2014-04-11) Holland, Mark
    Imaging has become an essential research tool in a majority of scientific disciplines. The IUPUI Imaging Research Initiative (IRI) has been established to bring together researcher investigators who develop innovative imaging technologies with those who utilize imaging tools to advance their research with the primary objective of building a large scale imaging research infrastructure at IUPUI. An Imaging Research Council has been created to establish priorities for the IRI and help guide the development of an IUPUI research imaging infrastructure and sustainable research funding base. The goals of the IUPUI Imaging Research Initiative include: • To encourage and coordinate collaboration among IUPUI researchers from different disciplines • To provide advice and guidance in the realization of highly competitive large grant proposals that will support and grow the IUPUI imaging efforts into major nationally and internationally recognized programs • To develop a strategic plan that will enable IUPUI to become nationally and internationally known as the place for innovative imaging research and its applications • To determine strategic areas of strength and growth • To determine available and needed resources • To determine strategic external partnerships
  • Thumbnail Image
    Item
    IUPUI Imaging Research Initiative: Research Center for Quantitative Renal Imaging
    (Office of the Vice Chancellor for Research, 2014-04-11) Holland, Mark
    Mission: The overall mission of the Research Center for Quantitative Renal Imaging is to provide a focused research environment and resource for the development, implementation, and dissemination of innovative, quantitative imaging methods designed to assess the status of and mechanisms associated with acute and chronic kidney disease and evaluate efficacy of therapeutic interventions. Currently, there is no comprehensive research center within the United States that is solely dedicated to the development of quantitative imaging methods specifically designed to diagnose kidney disease, monitor its progression, and evaluate efficacy of therapeutic interventions. The Research Center for Quantitative Renal Imaging represents a very unique resource within the nephrology and medical imaging communities that is distinctly associated with IUPUI and the IU School of Medicine. Nature of the Center: Our plan is to build upon the individually successful research programs and infrastructure that currently exist within our institution and weave these individual components into a new, unified, and unique Research Center focused on developing novel and innovative methods for quantitative imaging of the kidney. Goals: The Research Center for Quantitative Renal Imaging will achieve its mission by: • Identifying, developing, and implementing innovative imaging methods that provide quantitative imaging biomarkers for assessing and inter-relating renal structure, function, hemodynamics and underlying tissue microenvironmental factors contributing to kidney disease. • Establishing an environment that facilitates and encourages interdisciplinary collaborations among investigators, helps advance the research careers of junior faculty, and offers research support to investigators focused on developing and utilizing innovative quantitative imaging methods in support of kidney disease research. • Providing a resource to inform the greater research and healthcare communities of advances in quantitative renal imaging and its potential for enhanced patient management and care. • Offering an imaging research resource to pharmaceutical companies and medical device manufacturers engaged in product development associated with the diagnosis and treatment of kidney disease.
  • Thumbnail Image
    Item
    The 'bIUreactor': An Open-Source 3D Tissue Research Platform
    (Springer, 2024) Butch, Elizabeth; Prideaux, Matthew; Holland, Mark; Phan, Justin‑Thuy; Trent, Cole; Soon, Victor; Hutchins, Gary; Smith, Lester; Radiology and Imaging Sciences, School of Medicine
    We developed the open-source bIUreactor research platform for studying 3D structured tissues. The versatile and modular platform allows a researcher to generate 3D tissues, culture them with oxygenated perfusion, and provide cyclic loading, all in their own lab (in laboratorium) for an all in cost of $8,000 including 3D printer, printing resin, and electronics. We achieved this by applying a design philosophy that leverages 3D printing, open-source software and hardware, and practical techniques to produce the following: 1. perfusible 3D tissues, 2. a bioreactor chamber for tissue culture, 3. a module for applying cyclic compression, 4. a peristaltic pump for providing oxygenated perfusion to 3D tissues, 5. motor control units, and 6. open-source code for running the control units. By making it widely available for researchers to investigate 3D tissue models and easy for them to use, we intend for the bIUreactor to democratize 3D tissue research, therefore increasing the pace and scale of biomedical research discoveries using 3D tissue models.