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Browsing by Author "Hashmi, Zubair A."
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Item Identification and management of atypical Hemolytic Uremic Syndrome immediately post heart transplantation(Wiley, 2015-04) Vardas, Panos N.; Hashmi, Zubair A.; Hadi, M. Azam; Department of Medicine, IU School of MedicineAtypical hemolytic uremic syndrome (aHUS) is a serious hematologic disorder with high mortality if left untreated. A comprehensive literature review revealed only two cases of aHUS post–heart transplantation. In both cases the disease developed after induction of calcineurin inhibitor therapy. We report a case of immediate post–heart transplantation aHUS, manifested before the induction of, and therefore not associated with, calcineurin inhibitorsItem Intracellular Ca2+ Dysregulation in Coronary Smooth Muscle Is Similar in Coronary Disease of Humans and Ossabaw Miniature Swine(Springer, 2022-02) Badin, Jill K.; Eggenberger, Caleb; Rodenbeck, Stacey Dineen; Hashmi, Zubair A.; Wang, I-wen; Garcia, Jose P.; Alloosh, Mouhamad; Sturek, Michael; Anatomy and Cell Biology, School of MedicineIntracellular free Ca2+ ([Ca2+]i) dysregulation occurs in coronary smooth muscle (CSM) in atherosclerotic coronary artery disease (CAD) of metabolic syndrome (MetS) swine. Our goal was to determine how CAD severity, arterial structure, and MetS risk factors associate with [Ca2+]i dysregulation in human CAD compared to changes in Ossabaw miniature swine. CSM cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and MetS swine with CAD. CSM [Ca2+]i elicited by Ca2+ influx and sarcoplasmic reticulum (SR) Ca2+ release and sequestration was measured with fura-2. Increased [Ca2+]i signaling was associated with advanced age and a greater media area in human CAD. Decreased [Ca2+]i signaling was associated with a greater number of risk factors and a higher plaque burden in human and swine CAD. Similar [Ca2+]i dysregulation exhibited in human and Ossabaw swine CSM provides strong evidence for the translational relevance of this large animal model.Item Left ventricular thrombus associated with arteriovenous extra corporeal membrane oxygenation(Pioneer Bioscience Publishing Company, 2015-11) Makdisi, George; Hashmi, Zubair A.; Wozniak, Thomas C.; Wang, I.-Wen; Department of Surgery, IU School of MedicineExtra corporeal membrane oxygenation (ECMO) has remarkably progressed over the recent years. It has become an invaluable tool in the care of adults and pediatric patients with severe cardiogenic shock. At the initiation of ECMO support, the left ventricular contractility is profoundly impaired. Inadequate right ventricular drainage and bronchial circulation can lead to left ventricular distension, with potential deleterious consequences, ranging from inadequate myocardial rest, pulmonary edema, or intracardiac clot formation. Therefore, it is of extreme importance to ensure an adequate left ventricular drainage. Here we present a case of LV thrombus developed while the patient is on central venoarterial (VA) ECMO.Item A successful percutaneous mechanical vegetation debulking used as a bridge to surgery in acute tricuspid valve endocarditis(The Society for Thoracic Disease, 2016-01-29) Makdisi, George; Casciani, Thomas; Wozniak, Thomas C.; Roe, David W.; Hashmi, Zubair A.; Department of Radiology and Imaging Sciences, IU School of MedicineTiming of surgical management of acute infective endocarditis is a major challenge, with respect to surgical complications, risks of recurrences and optimal valve repair or replacement. We present a case of a 24-year-old male with a history of intravenous drug abuse, who was referred to our center after 10 days of medical management of acute infective endocarditis. Upon arrival he was in septic shock, multi-organ failure, and mobile vegetations on the tricuspid valve with severe tricuspid regurgitation. He also had bilateral pulmonary infarcts and an ischemic stroke in the right parietal lobe. A successful percutaneous transcatheter mechanical vegetation debulking was performed followed by surgical valve replacement seven days later. This case introduces a new option in the management of right-sided endocarditis in critically ill patient, and demonstrates the technical feasibility of a debulking procedure in this setting, which led subsequently to a significant improvement in patient’s condition, and he was ultimately able to undergo definitive surgery.