- Browse by Author
Browsing by Author "Hakami, Fatimah H."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item COVID-19 vaccine had a significant positive impact on patients with SARS-COV-2 during the third (Omicron) wave in Saudi Arabia(Elsevier, 2022) AlBahrani, Salma; AlBarrak, Ali; Al-Musawi, Tariq; AlGubaisi, Nawal Ali; Almalki, Maram; Hakami, Fatimah H.; Alghamdi, Turki; AlBeiuruti, Zena; Alkhrashi, Sausan; Almershad, Meshael; Alzahrani, Samira; AlQuraiaan, Amerah; AlTourifi, Helmy; Jebakumar, Arulanantham Zechariah; Al-Tawfiq, Jaffar A.; Medicine, School of MedicineIntroduction: The third (Omicron) wave had caused significant increase in the number of COVID-19 cases around the globe. The severity of the disease dependeds on the extent of the vaccination status. Methods: This is a retrospective study of infected COVID-19 patients during the third (Omicron) wave in a hospital in Saudi Arabia. Results: A total of 400 patients were included with 220 (55 %) males and 180 (45 %) females, and a mean age (+/- SD) of 36.34 + 16.47 years. The most common presenting symptoms were: sore throat 159 (39.8 %), cough 158 (39.5 %), fever 132 (33 %), headache 122 (30.5 %), and muscle ache 124 (31%). There was no difference in underlying conditions, signs and symptoms between males and females apart from the occurrence of sore throat with an OR of 2.014 (95 % CI: 1.103-3.677, P = 0.023) and need of hospitalization OR 2.457 (95 % CI: 1.168-5.167, P value =.018) in a binary logistic regression comparison. The need for hospitalization was inversely related to the number of COVID-19 vaccination doses. The rate of admission was 8 (72.7 %), 34 (12 %), 4 (5.4 %) for one, two, and three doses of COVID-19 vaccine, respectively (P < 0.0001). Of all the patients, 14 (3.5 %) and 8 (2 %) required intensive care (ICU) admission and mechanical ventilation, respectively. The median Ct-value of SARS-CoV-2 was higher in those who had 2 or 3 doses compared to those who had one dose of the COVID-19 vaccine, but the difference did not reach statistical significance. None of the included patients died during the study period. Conclusion: Omicron variant symptoms among infected patients are generally milder compared to other variants. Prior COVID-19 vaccination may limit disease severity and need for hospitalization.Item Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia(Elsevier, 2021-09) Al Bahrani, Salma; Albarrak, Ali; Alghamdi, Othman Ali; Alghamdi, Mesfer Abdullah; Hakami, Fatimah H.; Al Abaadi, Asmaa K.; Alkhrashi, Sausan A.; Alghamdi, Mansour Y.; Almershad, Meshael M.; Alenazi, Mansour Moklif; El Gezery, Mohamed Hany; Jebakumar, Arulanantham Zechariah; Al-Tawfiq, Jaffar A.; Medicine, School of MedicineIntroduction The Kingdom of Saudi Arabia was one of the first countries to implement a COVID-19 vaccination program. This study estimated the safety and reactogenicity of the ChAdOx1-S vaccine after the first dose administered to adults. Methods This cross-sectional study included 1592 randomly selected vaccinees from April to May 2021. A questionnaire was delivered to the vaccinees via phone calls 7 and 21 days after the first vaccine dose. Results Of the 1592 vaccinees who had the first dose, the mean age was 37.4 (± 9.6) years and 81% were males. Of all the vaccinees, 553 (34.7%) reported an adverse reaction on the first telephone call. The most common symptoms were: pain at the site of injection (485, 30.5%), musculoskeletal symptoms (438, 27.5%), skin rash (307, 19.2%), gastrointestinal symptoms (379, 23.8%) and fever (498, 31.3%). Men were more likely to report fever (76.9% vs. 23.1%; P = 0.005), skin rash (81.1% vs. 18.9%, P = 0.005) and pain at the injection site (77.3% vs. 22.7%, P < 0.0001). Post-vaccine COVID-19 infection was 0.5% and there were no hospitalizations. Conclusion This study observed no major side effects of the ChAdOx1-S vaccine and no reported breakthrough infection during the observation period.