Browsing by Author "Guerrero, Daniel"

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    Resting State Functional Connectivity Patterns Associate with Alcohol Use Disorder Characteristics: Insights from the Triple Network Model
    (ArXiv, 2025-04-08) Guerrero, Daniel; Dzemidzic, Mario; Moghaddam, Mahdi; Liu, Mintao; Avena-Koenigsberger, Andrea; Harezlak, Jaroslaw; Kareken, David A.; Plawecki, Martin H.; Cyders, Melissa A.; Goñi, Joaquín; Neurology, School of Medicine
    Prolonged alcohol use results in neuroadaptations that mark more severe and treatment-resistant alcohol use. The goal of this study was to identify functional connectivity brain patterns underlying Alcohol Use Disorder (AUD)-related characteristics in fifty-five adults (31 female) who endorsed heavy alcohol use. We hypothesized that resting-state functional connectivity (rsFC) of the Salience (SN), Frontoparietal (FPN), and Default Mode (DMN) networks would reflect self-reported recent and lifetime alcohol use, laboratory-based alcohol seeking, urgency, and sociodemographic characteristics related to AUD. To test our hypothesis, we combined the triple network model (TNM) of psychopathology with a multivariate data-driven approach, regularized partial least squares (rPLS), to unfold concurrent functional connectivity (FC) patterns and their association with AUD characteristics. We observed three concurrent associations of interest: i) drinking and age-related cross communication between the SN and both the FPN and DMN; ii) family history density of AUD and urgency anticorrelations between the SN and FPN; and iii) alcohol seeking and sex-associated SN and DMN interactions. These findings demonstrate the utility of combining theory- and data-driven approaches to uncover associations between resting-state functional substrates and AUD-related characteristics that could aid in the identification, development, and testing of novel treatment targets across preclinical and clinical models.
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    Tangent space functional reconfigurations in individuals at risk for alcohol use disorder
    (ArXiv, 2024-05-24) Moghaddam, Mahdi; Dzemidzic, Mario; Guerrero, Daniel; Liu, Mintao; Alessi, Jonathan; Plawecki, Martin H.; Harezlak, Jaroslaw; Kareken, David; Goñi, Joaquín; Neurology, School of Medicine
    Human brain function dynamically adjusts to ever-changing stimuli from the external environment. Studies characterizing brain functional reconfiguration are nevertheless scarce. Here we present a principled mathematical framework to quantify brain functional reconfiguration when engaging and disengaging from a stop signal task (SST). We apply tangent space projection (a Riemannian geometry mapping technique) to transform functional connectomes (FCs) and quantify functional reconfiguration using the correlation distance of the resulting tangent-FCs. Our goal was to compare functional reconfigurations in individuals at risk for alcohol use disorder (AUD). We hypothesized that functional reconfigurations when transitioning in/from a task would be influenced by family history of alcohol use disorder (FHA) and other AUD risk factors. Multilinear regression model results showed that engaging and disengaging functional reconfiguration were driven by different AUD risk factors. Functional reconfiguration when engaging in the SST was negatively associated with recent drinking. When disengaging from the SST, however, functional reconfiguration was negatively associated with FHA. In both models, several other factors contributed to the explanation of functional reconfiguration. This study demonstrates that tangent-FCs can characterize task-induced functional reconfiguration, and that it is related to AUD risk.
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    Tangent space functional reconfigurations in individuals at risk for alcohol use disorder
    (MIT Press, 2025-03-03) Moghaddam, Mahdi; Dzemidzic, Mario; Guerrero, Daniel; Liu, Mintao; Alessi, Jonathan; Plawecki, Martin H.; Harezlak, Jaroslaw; Kareken, David A.; Goñi, Joaquín; Neurology, School of Medicine
    Human brain function dynamically adjusts to ever-changing stimuli from the external environment. Studies characterizing brain functional reconfiguration are, nevertheless, scarce. Here, we present a principled mathematical framework to quantify brain functional reconfiguration when engaging and disengaging from a stop signal task (SST). We apply tangent space projection (a Riemannian geometry mapping technique) to transform the functional connectomes (FCs) of 54 participants and quantify functional reconfiguration using the correlation distance of the resulting tangent-FCs. Our goal was to compare functional reconfigurations in individuals at risk for alcohol use disorder (AUD). We hypothesized that functional reconfigurations when transitioning to/from a task would be influenced by family history of AUD (FHA) and other AUD risk factors. Multilinear regression models showed that engaging and disengaging functional reconfiguration were associated with FHA and recent drinking. When engaging in the SST after a rest condition, functional reconfiguration was negatively associated with recent drinking, while functional reconfiguration when disengaging from the SST was negatively associated with FHA. In both models, several other factors contributed to the functional reconfiguration. This study demonstrates that tangent-FCs can characterize task-induced functional reconfiguration and that it is related to AUD risk.