Browsing by Author "Gorwitz, Rachel J."

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    Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection
    (Oxford, 2017-06) Bakshi, Rakesh; Gupta, Kanupriya; Jordan, Stephen J.; Brown, Ladraka' T.; Press, Christen G.; Gorwitz, Rachel J.; Papp, John R.; Morrison, Sandra G.; Lee, Jeannette Y.; Morrison, Richard P.; Geisler, William M.; Medicine, School of Medicine
    Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. Of these women, 71.4% were IgG1+IgG3+, consistent with more recent chlamydia resolution. 15.6% were IgG3− at both visits, suggesting absence of recent chlamydia. Using elementary body ELISA, we demonstrated approximately 1 in 6 women classified as having spontaneous resolution of chlamydia might have been exposed to C. trachomatis but not infected. Further, we classified their possible infection stage.