Browsing by Author "Gale, David D."

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    Metacarpophalangeal pattern profile analysis in diastrophic dysplasia
    (Wiley, 1987-11) Butler, Merlin G.; Gale, David D.; Meaney, F. John; Medical and Molecular Genetics, School of Medicine
    We analyzed the metacarpophalangeal pattern profile (MCPP) on 16 individuals with diastrophic dysplasia and calculated a mean syndrome profile. Correlation studies confirm clinical homogeneity of the hand profile in diastrophic dysplasia. Discriminant analysis of individuals with diastrophic dysplasia compared with a sample of normal individuals produced a function of 3 MCPP variables plus age that appears to be a useful diagnostic tool.
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    Metacarpophalangeal pattern profile analysis in Robinow syndrome
    (Wiley, 1987-05) Butler, Merlin G.; Gale, David D.; Meaney, F. John; Wadlington, William B.; Robinow, Meinhard; Medical and Molecular Genetics, School of Medicine
    We analyzed the metacarpophalangeal pattern profile (MCPP) on 15 individuals with Robinow syndrome and calculated a mean Robinow syndrome profile. Correlation studies confirm clinical homogeneity of the hand profile in the Robinow syndrome. Discriminant analysis of individuals with Robinow syndrome compared with a sample of normal individuals produces a function of 6 MCPP variable that may provide a useful tool for diagnosis.
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    Metacarpophalangeal Pattern Profile Analysis in Sotos Syndrome: A Follow-up Report on 34 Subjects
    (Wiley, 1988-01) Butler, Merlin G.; Dijkstra, Piet F.; Meaney, F. John; Gale, David D.; Medical and Molecular Genetics, School of Medicine
    Metacarpophalangeal pattern profile (MCPP) was determined on 34 Sotos syndrome individuals and compared with previous MCPP studies. The mean hand profile contained a major peak in the proximal phalangeal area and a smaller peak in the metacarpal area, while the distal hand bones were relatively short. There appear to be three recognized hand profiles in Sotos syndrome, which suggests heterogeneity of the syndrome, although correlation studies indicate clinical homogeneity of individuals in the younger age groups. Discriminant analysis of Sotos syndrome versus control subjects produced a function of two MCPP variables, plus age, which may be applied as another diagnostic tool.